Microscale Control of Stiffness in a Cell-Adhesive Substrate Using Microfluidics-Based Lithography

被引：41

作者：

Cheung, Yuk Kee ^{[1
]}

Azeloglu, Evren U. ^{[1
]}

Shiovitz, David A. ^{[1
]}

Costa, Kevin D. ^{[1
]}

Seliktar, Dror ^{[2
]}

Sia, Samuel K. ^{[1
]}

机构：

[1] Columbia Univ, Dept Biomed Engn, New York, NY 10027 USA

[2] Technion Israel Inst Technol, Dept Biomed Engn, IL-32000 Haifa, Israel

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 39期

关键词：

hydrogels; mechanosensing; microfabrication; micofluidics; polymerization; ATOMIC-FORCE MICROSCOPE; MECHANICAL-PROPERTIES; EXTRACELLULAR-MATRIX; HYDROGELS; ELASTICITY; MICROSTRUCTURES; HETEROGENEITY; INDENTATION; FLEXIBILITY; MIGRATION;

D O I：

10.1002/anie.200900807

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Microfluidics-based lithography based on microfluidics is used to pattern cell-adhesive hydrogel substrates with micro-variations in stiffness. The micropatterns are generated by feeding PEG-fibrinogen and various amounts of polyethylene glycol diacrylate (PEGDA) into the micofluidic channel (see picture). © 2009 Wiley-VCH Verlag GmbH & Co. KCaA.

引用

页码：7188 / 7192

页数：5

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