Multiple functions of the origin recognition complex

被引:47
作者
Chesnokov, Igor N. [1 ]
机构
[1] Univ Alabama Birmingham, Sch Med, Dept Biochem & Mol Genet, Birmingham, AL 35294 USA
来源
INTERNATIONAL REVIEW OF CYTOLOGY - A SURVEY OF CELL BIOLOGY, VOL 256 | 2007年 / 256卷
关键词
origin recognition complex; DNA replication; chromatin; cytokinesis;
D O I
10.1016/S0074-7696(07)56003-1
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The origin recognition complex (ORC), a heteromeric six-subunit protein, is a central component for eukaryotic DNA replication. The ORC binds to DNA at replication origin sites in an ATP-dependent manner and serves as a scaffold for the assembly of other key initiation factors. Sequence rules for ORC-DNA binding appear to vary widely. In budding yeast the ORC recognizes specific ori elements, however, in higher eukaryotes origin site selection does not appear to depend on the specific DNA sequence. In metazoans, during cell cycle progression, one or more of the ORC subunits can be modified in such a way that ORC activity is inhibited until mitosis is complete and a nuclear membrane is assembled. In addition to its well-documented role in the initiation of DNA replication, the ORC is also involved in other cell functions. Some of these activities directly link cell cycle progression with DNA replication, while other functions seem distinct from replication. The function of ORCs in the establishment of transcriptionally repressed regions is described for many species and may be a conserved feature common for both unicellular eukaryotes and metazoans. ORC subunits were found at centrosomes, at the cell membranes, at the cytokinesis furrows of dividing cells, as well as at the kinetochore. The exact mechanism of these localizations remains to be determined, however, latest results support the idea that ORC proteins participate in multiple aspects of the chromosome inheritance cycle. In this review, we discuss the participation of ORC proteins in various cell functions, in addition to the canonical role of ORC in initiating DNA replication.
引用
收藏
页码:69 / +
页数:44
相关论文
共 175 条
[1]   Chromatin regulates origin activity in Drosophila follicle cells [J].
Aggarwal, BD ;
Calvi, BR .
NATURE, 2004, 430 (6997) :372-376
[2]   Genetic dissection of a mammalian replicator in the human β-globin locus [J].
Aladjem, MI ;
Rodewald, LW ;
Kolman, JL ;
Wahl, GM .
SCIENCE, 1998, 281 (5379) :1005-1009
[3]   Dynamics of DNA replication in mammalian somatic cells: Nucleotide pool modulates origin choice and interorigin spacing [J].
Anglana, M ;
Apiou, F ;
Bensimon, A ;
Debatisse, M .
CELL, 2003, 114 (03) :385-394
[4]   Components and dynamics of DNA replication complexes in S-cerevisiae: Redistribution of MCM proteins and Cdc45p during S phase [J].
Aparicio, OM ;
Weinstein, DM ;
Bell, SP .
CELL, 1997, 91 (01) :59-69
[5]   Degradation of origin recognition complex large subunit by the anaphase-promoting complex in Drosophila [J].
Araki, M ;
Wharton, RP ;
Tang, ZY ;
Yu, HT ;
Asano, M .
EMBO JOURNAL, 2003, 22 (22) :6115-6126
[6]   E2F mediates developmental and cell cycle regulation of ORC1 in Drosophila [J].
Asano, M ;
Wharton, RP .
EMBO JOURNAL, 1999, 18 (09) :2435-2448
[7]   Drosophila ORC specifically binds to ACE3, an origin of DNA replication control element [J].
Austin, RJ ;
Orr-Weaver, TL ;
Bell, SP .
GENES & DEVELOPMENT, 1999, 13 (20) :2639-2649
[8]   A ROLE FOR CDC7 IN REPRESSION OF TRANSCRIPTION AT THE SILENT MATING-TYPE LOCUS HMR IN SACCHAROMYCES-CEREVISIAE [J].
AXELROD, A ;
RINE, J .
MOLECULAR AND CELLULAR BIOLOGY, 1991, 11 (02) :1080-1091
[9]   Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain [J].
Bannister, AJ ;
Zegerman, P ;
Partridge, JF ;
Miska, EA ;
Thomas, JO ;
Allshire, RC ;
Kouzarides, T .
NATURE, 2001, 410 (6824) :120-124
[10]   Dm-myb mutant lethality in Drosophila is dependent upon mip130:: positive and negative 1667 regulation of DNA replication [J].
Beall, EL ;
Bell, M ;
Georlette, D ;
Botchan, MR .
GENES & DEVELOPMENT, 2004, 18 (14) :1667-1680