Recurrence of Crohn's Disease After Ileocolic Resection Is Not Affected by Anastomotic Type: Results of a Multicenter, Randomized, Controlled Trial

被引:202
作者
McLeod, Robin S. [1 ,2 ,3 ]
Wolff, Bruce G. [4 ]
Ross, Sue [5 ]
Parkes, Robert [1 ,3 ]
McKenzie, Margaret [2 ]
机构
[1] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada
[2] Univ Toronto, Dept Surg, Toronto, ON, Canada
[3] Univ Toronto, Dept Hlth Policy Management & Adm, Toronto, ON, Canada
[4] Mayo Clin, Dept Surg, Rochester, MN USA
[5] Univ Calgary, Dept Surg, Calgary, AB, Canada
关键词
Crohn's disease; Surgery; Randomized controlled trial; Postoperative recurrence; TO-END ANASTOMOSIS; SIDE STAPLED ANASTOMOSIS; HAND-SEWN ANASTOMOSES; RISK-FACTORS; SMALL-BOWEL; PATTERNS; MARGINS; LESIONS; VS;
D O I
10.1007/DCR.0b013e3181a4fa58
中图分类号
R57 [消化系及腹部疾病];
学科分类号
100201 [内科学];
摘要
PURPOSE: This study attempts to determine whether stapled side-to-side anastomosis, compared with handsewn end-to-end anastomosis, results in decreased recurrence of Crohn's disease following ileocolic resection. METHODS: Patients with Crohn's disease who underwent an ileocolic resection were randomized to side-to-side anastomosis or end-to-end anastomosis. Colonoscopy was performed at 12 months. The primary outcome was endoscopic recurrence, while the secondary outcome was symptomatic recurrence (defined as symptoms attributable to Crohn's disease and severe enough to warrant treatment, plus endoscopic disease recurrence). RESULTS: One hundred and thirty-nine subjects were included in the efficacy analysis. After a mean follow-up of 11.9 months, the endoscopic recurrence rate was 42.5 percent in the end-to-end anastomosis group, compared with 37.9 percent in the side-to-side anastomosis group (-4.6 percent difference; 95 percent confidence interval -21.0 to 11.9 percent; P = 0.55). The symptomatic recurrence rate was 21.9 percent in the end-to-end anastomosis group, compared with 22.7 percent in the side-to-side anastomosis group (+0.8 percent difference; 95 percent confidence interval -13.2 to 15.3 percent; P = 0.92). In multivariate logistic regression analysis, previous resections were predictive of a higher risk of both endoscopic (odds ratio 1.78; 95 percent confidence interval 1.06 to 2.90; P = 0.028) and symptomatic (odds ratio 2.0; 95 percent confidence interval 1.14 to 3.60; P = 0.0016) recurrence. Compliance with postoperative maintenance therapy was predictive of a lower risk of symptomatic recurrence (odds ratio 0.13, 95 percent confidence interval 0.01 to 0.78; P = 0.021). CONCLUSION: Recurrence rates are similar whether end-to-end anastomosis or side-to-side anastomosis is performed.
引用
收藏
页码:919 / 927
页数:9
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