Preliminary evaluation of dual wavelength phased array imaging on neonatal brain function

被引:16
作者
Chen, Y [1 ]
Zhou, SM
Xie, CH
Nioka, S
Delivoria-Papadopoulos, M
Anday, E
Chance, B
机构
[1] Univ Penn, Dept Biochem & Biophys, Philadelphia, PA 19104 USA
[2] Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA
[3] MCPHU, Dept Pediat, Div Neonatol, Philadelphia, PA 19132 USA
关键词
optical imaging; noninvasive diagnosis; phased array; neonate; functional brain imaging;
D O I
10.1117/1.429986
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Imaging of human tissue using noninvasive techniques has been of great interest in biomedical fields, Optical imaging has attracted a lot of attention because of its portability and economy. The possibility that a highly portable, fast, safe, and affordable imaging system which could obtain interpretable images of brain function for pre- and full-term neonates in a few seconds, has been explored in this article, We have used a sensitive optical topography system, termed phased array, in which a pair of equal-amplitude and antiphase light sources are applied to generate a sharp amplitude null and phase transition plane. This two-wavelength (750 and 830 nm), frequency encoded (50 and 52 MHz) phased array imaging system can indicate the blood concentration and oxygenation changes in blood model studies and during parietal brain activation in neonates. Significant functional responses, particularly to parietal stimulation in normal and pathological states of neonatal brain, have been revealed in our study. The preliminary clinical results are presented in this article. (C) 2000 Society of Photo-Optical Instrumentation Engineers. [S1083-3668(00)01002-9].
引用
收藏
页码:194 / 200
页数:7
相关论文
共 20 条
[1]  
BRAZY JE, 1985, PEDIATRICS, V75, P217
[2]   Precision localization of hidden absorbers in body tissues with phased-array optical systems [J].
Chance, B ;
Kang, KA ;
He, LB ;
Liu, HL ;
Zhou, SM .
REVIEW OF SCIENTIFIC INSTRUMENTS, 1996, 67 (12) :4324-4332
[3]   HIGHLY SENSITIVE OBJECT LOCATION IN TISSUE MODELS WITH LINEAR IN-PHASE AND ANTIPHASE MULTIELEMENT OPTICAL ARRAYS IN ONE AND 2 DIMENSIONS [J].
CHANCE, B ;
KANG, K ;
HE, L ;
WENG, J ;
SEVICK, E .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (08) :3423-3427
[4]   A novel method for fast imaging of brain function, non-invasively, with light [J].
Chance, B ;
Anday, E ;
Nioka, S ;
Zhou, S ;
Hong, L ;
Worden, K ;
Li, C ;
Murray, T ;
Ovetsky, Y ;
Pidikiti, D ;
Thomas, R .
OPTICS EXPRESS, 1998, 2 (10) :411-423
[5]   Optical investigations of physiology: A study of intrinsic and extrinsic biomedical contrast [J].
Chance, B ;
Luo, QM ;
Nioka, S ;
Alsop, DC ;
Detre, JA .
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 1997, 352 (1354) :707-716
[6]  
Chance B., 1993, P NATL ACAD SCI USA, V90, P2660
[7]  
CHANCE B, 1998, OSA TOPS ADV OPT IMA, V21, P218
[8]   SYSTEM FOR LONG-TERM MEASUREMENT OF CEREBRAL BLOOD AND TISSUE OXYGENATION ON NEWBORN-INFANTS BY NEAR-INFRARED TRANS-ILLUMINATION [J].
COPE, M ;
DELPY, DT .
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, 1988, 26 (03) :289-294
[9]   PROPAGATION OF PHOTON-DENSITY WAVES IN STRONGLY SCATTERING MEDIA CONTAINING AN ABSORBING SEMIINFINITE PLANE BOUNDED BY A STRAIGHT EDGE [J].
FISHKIN, JB ;
GRATTON, E .
JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION, 1993, 10 (01) :127-140
[10]   MEASUREMENT OF SIGNAL INTENSITIES IN THE PRESENCE OF NOISE IN MR IMAGES [J].
HENKELMAN, RM .
MEDICAL PHYSICS, 1985, 12 (02) :232-233