共 90 条
The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection
被引:1232
作者:

Sharpe, Arlene H.
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

Wherry, E. John
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

Ahmed, Rafi
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

Freeman, Gordon J.
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA
机构:
[1] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA
[2] Brigham & Womens Hosp, Boston, MA 02115 USA
[3] Wistar Inst Anat & Biol, Program Immunol, Philadelphia, PA 19104 USA
[4] Emory Univ, Sch Med, Emory Vaccine Ctr, Atlanta, GA 30322 USA
[5] Emory Univ, Sch Med, Dept Microbiol & Immunol, Atlanta, GA 30322 USA
[6] Harvard Univ, Sch Med, Dept Med,Dept Med Oncol, Dana Farber Canc Inst, Boston, MA 02115 USA
基金:
美国国家卫生研究院;
关键词:
D O I:
10.1038/ni1443
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
The programmed cell death 1 (PD-1) surface receptor binds to two ligands, PD-L1 and PD-L2. Studies have shown that PD-1-PD-L interactions control the induction and maintenance of peripheral T cell tolerance and indicate a previously unknown function for PD-L1 on nonhematopoietic cells in protecting tissues from autoimmune attack. PD-1 and its ligands have also been exploited by a variety of microorganisms to attenuate antimicrobial immunity and facilitate chronic infection. Here we examine the functions of PD-1 and its ligands in regulating antimicrobial and self-reactive T cell responses and discuss the therapeutic potential of manipulating this pathway.
引用
收藏
页码:239 / 245
页数:7
相关论文
共 90 条
[1]
Induction of CTLA-4-mediated anergy contributes to persistent colonization in the murine model of gastric Helicobacter pylori infection
[J].
Anderson, Kathleen M.
;
Czinn, Steven J.
;
Redline, Raymond W.
;
Blanchard, Thomas G.
.
JOURNAL OF IMMUNOLOGY,
2006, 176 (09)
:5306-5313

Anderson, Kathleen M.
论文数: 0 引用数: 0
h-index: 0
机构: Case Western Reserve Univ, Sch Med, Dept Pathol, Cleveland, OH 44106 USA

Czinn, Steven J.
论文数: 0 引用数: 0
h-index: 0
机构: Case Western Reserve Univ, Sch Med, Dept Pathol, Cleveland, OH 44106 USA

Redline, Raymond W.
论文数: 0 引用数: 0
h-index: 0
机构: Case Western Reserve Univ, Sch Med, Dept Pathol, Cleveland, OH 44106 USA

Blanchard, Thomas G.
论文数: 0 引用数: 0
h-index: 0
机构: Case Western Reserve Univ, Sch Med, Dept Pathol, Cleveland, OH 44106 USA
[2]
The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice
[J].
Ansari, MJI
;
Salama, AD
;
Chitnis, T
;
Smith, RN
;
Yagita, H
;
Akiba, H
;
Yamazaki, T
;
Azuma, M
;
Iwai, H
;
Khoury, SJ
;
Auchincloss, H
;
Sayegh, MH
.
JOURNAL OF EXPERIMENTAL MEDICINE,
2003, 198 (01)
:63-69

Ansari, MJI
论文数: 0 引用数: 0
h-index: 0
机构: Brigham & Womens Hosp, Lab Immunogenet & Transplantat, Boston, MA 02115 USA

Salama, AD
论文数: 0 引用数: 0
h-index: 0
机构: Brigham & Womens Hosp, Lab Immunogenet & Transplantat, Boston, MA 02115 USA

Chitnis, T
论文数: 0 引用数: 0
h-index: 0
机构: Brigham & Womens Hosp, Lab Immunogenet & Transplantat, Boston, MA 02115 USA

Smith, RN
论文数: 0 引用数: 0
h-index: 0
机构: Brigham & Womens Hosp, Lab Immunogenet & Transplantat, Boston, MA 02115 USA

Yagita, H
论文数: 0 引用数: 0
h-index: 0
机构: Brigham & Womens Hosp, Lab Immunogenet & Transplantat, Boston, MA 02115 USA

Akiba, H
论文数: 0 引用数: 0
h-index: 0
机构: Brigham & Womens Hosp, Lab Immunogenet & Transplantat, Boston, MA 02115 USA

Yamazaki, T
论文数: 0 引用数: 0
h-index: 0
机构: Brigham & Womens Hosp, Lab Immunogenet & Transplantat, Boston, MA 02115 USA

Azuma, M
论文数: 0 引用数: 0
h-index: 0
机构: Brigham & Womens Hosp, Lab Immunogenet & Transplantat, Boston, MA 02115 USA

Iwai, H
论文数: 0 引用数: 0
h-index: 0
机构: Brigham & Womens Hosp, Lab Immunogenet & Transplantat, Boston, MA 02115 USA

Khoury, SJ
论文数: 0 引用数: 0
h-index: 0
机构: Brigham & Womens Hosp, Lab Immunogenet & Transplantat, Boston, MA 02115 USA

Auchincloss, H
论文数: 0 引用数: 0
h-index: 0
机构: Brigham & Womens Hosp, Lab Immunogenet & Transplantat, Boston, MA 02115 USA

Sayegh, MH
论文数: 0 引用数: 0
h-index: 0
机构: Brigham & Womens Hosp, Lab Immunogenet & Transplantat, Boston, MA 02115 USA
[3]
Bone marrow mesenchymal progenitor cells inhibit lymphocyte proliferation by activation of the programmed death 1 pathway
[J].
Augello, A
;
Tasso, R
;
Negrini, SM
;
Amateis, A
;
Indiveri, F
;
Cancedda, R
;
Pennesi, G
.
EUROPEAN JOURNAL OF IMMUNOLOGY,
2005, 35 (05)
:1482-1490

Augello, A
论文数: 0 引用数: 0
h-index: 0
机构: Natl Inst Canc Res, Dept Innovat Therapies, Lab Regenerat Med, I-16132 Genoa, Italy

Tasso, R
论文数: 0 引用数: 0
h-index: 0
机构: Natl Inst Canc Res, Dept Innovat Therapies, Lab Regenerat Med, I-16132 Genoa, Italy

Negrini, SM
论文数: 0 引用数: 0
h-index: 0
机构: Natl Inst Canc Res, Dept Innovat Therapies, Lab Regenerat Med, I-16132 Genoa, Italy

Amateis, A
论文数: 0 引用数: 0
h-index: 0
机构: Natl Inst Canc Res, Dept Innovat Therapies, Lab Regenerat Med, I-16132 Genoa, Italy

Indiveri, F
论文数: 0 引用数: 0
h-index: 0
机构: Natl Inst Canc Res, Dept Innovat Therapies, Lab Regenerat Med, I-16132 Genoa, Italy

Cancedda, R
论文数: 0 引用数: 0
h-index: 0
机构: Natl Inst Canc Res, Dept Innovat Therapies, Lab Regenerat Med, I-16132 Genoa, Italy

Pennesi, G
论文数: 0 引用数: 0
h-index: 0
机构: Natl Inst Canc Res, Dept Innovat Therapies, Lab Regenerat Med, I-16132 Genoa, Italy
[4]
Restoring function in exhausted CD8 T cells during chronic viral infection
[J].
Barber, DL
;
Wherry, EJ
;
Masopust, D
;
Zhu, BG
;
Allison, JP
;
Sharpe, AH
;
Freeman, GJ
;
Ahmed, R
.
NATURE,
2006, 439 (7077)
:682-687

Barber, DL
论文数: 0 引用数: 0
h-index: 0
机构: Emory Univ, Sch Med, Emory Vaccine Ctr, Atlanta, GA 30322 USA

Wherry, EJ
论文数: 0 引用数: 0
h-index: 0
机构: Emory Univ, Sch Med, Emory Vaccine Ctr, Atlanta, GA 30322 USA

Masopust, D
论文数: 0 引用数: 0
h-index: 0
机构: Emory Univ, Sch Med, Emory Vaccine Ctr, Atlanta, GA 30322 USA

Zhu, BG
论文数: 0 引用数: 0
h-index: 0
机构: Emory Univ, Sch Med, Emory Vaccine Ctr, Atlanta, GA 30322 USA

Allison, JP
论文数: 0 引用数: 0
h-index: 0
机构: Emory Univ, Sch Med, Emory Vaccine Ctr, Atlanta, GA 30322 USA

Sharpe, AH
论文数: 0 引用数: 0
h-index: 0
机构: Emory Univ, Sch Med, Emory Vaccine Ctr, Atlanta, GA 30322 USA

Freeman, GJ
论文数: 0 引用数: 0
h-index: 0
机构: Emory Univ, Sch Med, Emory Vaccine Ctr, Atlanta, GA 30322 USA

Ahmed, R
论文数: 0 引用数: 0
h-index: 0
机构:
Emory Univ, Sch Med, Emory Vaccine Ctr, Atlanta, GA 30322 USA Emory Univ, Sch Med, Emory Vaccine Ctr, Atlanta, GA 30322 USA
[5]
HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells
[J].
Betts, Michael R.
;
Nason, Martha C.
;
West, Sadie M.
;
De Rosa, Stephen C.
;
Migueles, Stephen A.
;
Abraham, Jonathan
;
Lederman, Michael M.
;
Benito, Jose M.
;
Goepfert, Paul A.
;
Connors, Mark
;
Roederer, Mario
;
Koup, Richard A.
.
BLOOD,
2006, 107 (12)
:4781-4789

Betts, Michael R.
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Immunol Lab, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA

Nason, Martha C.
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Immunol Lab, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA

West, Sadie M.
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Immunol Lab, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA

De Rosa, Stephen C.
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Immunol Lab, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA

Migueles, Stephen A.
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Immunol Lab, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA

Abraham, Jonathan
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Immunol Lab, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA

Lederman, Michael M.
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Immunol Lab, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA

Benito, Jose M.
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Immunol Lab, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA

Goepfert, Paul A.
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Immunol Lab, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA

Connors, Mark
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Immunol Lab, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA

Roederer, Mario
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Immunol Lab, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA

Koup, Richard A.
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Immunol Lab, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA
[6]
Characterization of functional and phenotypic changes in anti-Gag vaccine-induced T cell responses and their role in protection after HIV-1 infection
[J].
Betts, MR
;
Exley, B
;
Price, DA
;
Bansal, A
;
Camacho, ZT
;
Teaberry, V
;
West, SM
;
Ambrozak, DR
;
Tomaras, G
;
Roederer, M
;
Kilby, JM
;
Tartaglia, J
;
Belshe, R
;
Gao, F
;
Douek, DC
;
Weinhold, KJ
;
Koup, RA
;
Goepfert, P
;
Ferrari, G
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
2005, 102 (12)
:4512-4517

Betts, MR
论文数: 0 引用数: 0
h-index: 0
机构: Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA

Exley, B
论文数: 0 引用数: 0
h-index: 0
机构: Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA

Price, DA
论文数: 0 引用数: 0
h-index: 0
机构: Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA

Bansal, A
论文数: 0 引用数: 0
h-index: 0
机构: Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA

Camacho, ZT
论文数: 0 引用数: 0
h-index: 0
机构: Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA

Teaberry, V
论文数: 0 引用数: 0
h-index: 0
机构: Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA

West, SM
论文数: 0 引用数: 0
h-index: 0
机构: Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA

Ambrozak, DR
论文数: 0 引用数: 0
h-index: 0
机构: Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA

Tomaras, G
论文数: 0 引用数: 0
h-index: 0
机构: Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA

Roederer, M
论文数: 0 引用数: 0
h-index: 0
机构: Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA

Kilby, JM
论文数: 0 引用数: 0
h-index: 0
机构: Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA

Tartaglia, J
论文数: 0 引用数: 0
h-index: 0
机构: Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA

Belshe, R
论文数: 0 引用数: 0
h-index: 0
机构: Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA

Gao, F
论文数: 0 引用数: 0
h-index: 0
机构: Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA

Douek, DC
论文数: 0 引用数: 0
h-index: 0
机构: Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA

Weinhold, KJ
论文数: 0 引用数: 0
h-index: 0
机构: Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA

Koup, RA
论文数: 0 引用数: 0
h-index: 0
机构: Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA

论文数: 引用数:
h-index:
机构:

Ferrari, G
论文数: 0 引用数: 0
h-index: 0
机构: Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA
[7]
Absence of programmed death receptor 1 alters thymic development and enhances generation of CD4/CD8 double-negative TCR-transgenic T cells
[J].
Blank, C
;
Brown, I
;
Marks, R
;
Nishimura, H
;
Honjo, T
;
Gajewski, TF
.
JOURNAL OF IMMUNOLOGY,
2003, 171 (09)
:4574-4581

Blank, C
论文数: 0 引用数: 0
h-index: 0
机构: Univ Chicago, Sect Hematol Oncol & Committee Immunol, Dept Med, Dept Pathol, Chicago, IL 60637 USA

Brown, I
论文数: 0 引用数: 0
h-index: 0
机构: Univ Chicago, Sect Hematol Oncol & Committee Immunol, Dept Med, Dept Pathol, Chicago, IL 60637 USA

Marks, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Chicago, Sect Hematol Oncol & Committee Immunol, Dept Med, Dept Pathol, Chicago, IL 60637 USA

Nishimura, H
论文数: 0 引用数: 0
h-index: 0
机构: Univ Chicago, Sect Hematol Oncol & Committee Immunol, Dept Med, Dept Pathol, Chicago, IL 60637 USA

Honjo, T
论文数: 0 引用数: 0
h-index: 0
机构: Univ Chicago, Sect Hematol Oncol & Committee Immunol, Dept Med, Dept Pathol, Chicago, IL 60637 USA

Gajewski, TF
论文数: 0 引用数: 0
h-index: 0
机构: Univ Chicago, Sect Hematol Oncol & Committee Immunol, Dept Med, Dept Pathol, Chicago, IL 60637 USA
[8]
RETRACTED: Induction of a gene expression program in dendritic cells with a cross-linking IgM antibody to the co-stimulatory molecule B7-DC (Retracted Article. See vol 24, pg 2135, 2010)
[J].
Blocki, Frank A.
;
Radhakrishnan, Suresh
;
Van Keulen, Virginia P.
;
Heckman, Karin L.
;
Ciric, Bogoljub
;
Howe, Charles L.
;
Rodriguez, Moses
;
Kwon, Eugene
;
Pease, Larry R.
.
FASEB JOURNAL,
2006, 20 (13)
:2408-+

Blocki, Frank A.
论文数: 0 引用数: 0
h-index: 0
机构: Mayo Clin & Mayo Fdn, Coll Med, Dept Immunol, Rochester, MN 55905 USA

Radhakrishnan, Suresh
论文数: 0 引用数: 0
h-index: 0
机构: Mayo Clin & Mayo Fdn, Coll Med, Dept Immunol, Rochester, MN 55905 USA

Van Keulen, Virginia P.
论文数: 0 引用数: 0
h-index: 0
机构: Mayo Clin & Mayo Fdn, Coll Med, Dept Immunol, Rochester, MN 55905 USA

Heckman, Karin L.
论文数: 0 引用数: 0
h-index: 0
机构: Mayo Clin & Mayo Fdn, Coll Med, Dept Immunol, Rochester, MN 55905 USA

Ciric, Bogoljub
论文数: 0 引用数: 0
h-index: 0
机构: Mayo Clin & Mayo Fdn, Coll Med, Dept Immunol, Rochester, MN 55905 USA

Howe, Charles L.
论文数: 0 引用数: 0
h-index: 0
机构: Mayo Clin & Mayo Fdn, Coll Med, Dept Immunol, Rochester, MN 55905 USA

Rodriguez, Moses
论文数: 0 引用数: 0
h-index: 0
机构: Mayo Clin & Mayo Fdn, Coll Med, Dept Immunol, Rochester, MN 55905 USA

Kwon, Eugene
论文数: 0 引用数: 0
h-index: 0
机构: Mayo Clin & Mayo Fdn, Coll Med, Dept Immunol, Rochester, MN 55905 USA

Pease, Larry R.
论文数: 0 引用数: 0
h-index: 0
机构: Mayo Clin & Mayo Fdn, Coll Med, Dept Immunol, Rochester, MN 55905 USA
[9]
Expression of the interleukin-7 receptor alpha chain (CD127) on virus-specific CD8+ T cells identifies functionally and phenotypically defined memory T cells during acute resolving hepatitis B virus infection
[J].
Boettler, T
;
Panther, E
;
Bengsch, B
;
Nazarova, N
;
Spangenberg, HC
;
Blum, HE
;
Thimme, R
.
JOURNAL OF VIROLOGY,
2006, 80 (07)
:3532-3540

Boettler, T
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Freiburg, Dept Med 2, D-79106 Freiburg, Germany Univ Hosp Freiburg, Dept Med 2, D-79106 Freiburg, Germany

Panther, E
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Freiburg, Dept Med 2, D-79106 Freiburg, Germany Univ Hosp Freiburg, Dept Med 2, D-79106 Freiburg, Germany

Bengsch, B
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Freiburg, Dept Med 2, D-79106 Freiburg, Germany Univ Hosp Freiburg, Dept Med 2, D-79106 Freiburg, Germany

Nazarova, N
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Freiburg, Dept Med 2, D-79106 Freiburg, Germany Univ Hosp Freiburg, Dept Med 2, D-79106 Freiburg, Germany

Spangenberg, HC
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Freiburg, Dept Med 2, D-79106 Freiburg, Germany Univ Hosp Freiburg, Dept Med 2, D-79106 Freiburg, Germany

Blum, HE
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Freiburg, Dept Med 2, D-79106 Freiburg, Germany Univ Hosp Freiburg, Dept Med 2, D-79106 Freiburg, Germany

Thimme, R
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Freiburg, Dept Med 2, D-79106 Freiburg, Germany Univ Hosp Freiburg, Dept Med 2, D-79106 Freiburg, Germany
[10]
Blockade of programmed death-1 Ligands on dendritic cells enhances T cell activation and cytokine production
[J].
Brown, JA
;
Dorfman, DM
;
Ma, FR
;
Sullivan, EL
;
Munoz, O
;
Wood, CR
;
Greenfield, EA
;
Freeman, GJ
.
JOURNAL OF IMMUNOLOGY,
2003, 170 (03)
:1257-1266

Brown, JA
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

Dorfman, DM
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

Ma, FR
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

Sullivan, EL
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

Munoz, O
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

Wood, CR
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

Greenfield, EA
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

Freeman, GJ
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA