The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection

被引:1232
作者
Sharpe, Arlene H. [1 ]
Wherry, E. John
Ahmed, Rafi
Freeman, Gordon J.
机构
[1] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA
[2] Brigham & Womens Hosp, Boston, MA 02115 USA
[3] Wistar Inst Anat & Biol, Program Immunol, Philadelphia, PA 19104 USA
[4] Emory Univ, Sch Med, Emory Vaccine Ctr, Atlanta, GA 30322 USA
[5] Emory Univ, Sch Med, Dept Microbiol & Immunol, Atlanta, GA 30322 USA
[6] Harvard Univ, Sch Med, Dept Med,Dept Med Oncol, Dana Farber Canc Inst, Boston, MA 02115 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1038/ni1443
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The programmed cell death 1 (PD-1) surface receptor binds to two ligands, PD-L1 and PD-L2. Studies have shown that PD-1-PD-L interactions control the induction and maintenance of peripheral T cell tolerance and indicate a previously unknown function for PD-L1 on nonhematopoietic cells in protecting tissues from autoimmune attack. PD-1 and its ligands have also been exploited by a variety of microorganisms to attenuate antimicrobial immunity and facilitate chronic infection. Here we examine the functions of PD-1 and its ligands in regulating antimicrobial and self-reactive T cell responses and discuss the therapeutic potential of manipulating this pathway.
引用
收藏
页码:239 / 245
页数:7
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