Surgical stress response

被引：112

作者：

Giannoudis, Peter V.

Dinopoulos, Haralambos

Chalidis, Byron

Hall, George M.

机构：

[1] Univ Leeds, LGI Univ Hosp, Sch Med, Acad Dept Trauma & Orthpaed Surg, Leeds, W Yorkshire, England

[2] Univ London, St Georges, Dept Anaesthesia & Intens Care Med, London SW17 0RE, England

来源：

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED | 2006年 / 37卷

关键词：

trauma; surgical stress; inflammatory response; cytokines;

D O I：

10.1016/S0020-1383(07)70005-0

中图分类号：

R4 [临床医学];

学科分类号：

1002 [临床医学]; 100602 [中西医结合临床];

摘要：

Recent advances in molecular medicine have allowed the characterization and quantification of inflammatory cascades following surgery and trauma. Activation of immune cells is followed by the release of various cytokines as well as by migration of leukocytes into inflamed tissues. Various methods have been developed in order to modulate the immune-inflammatory system and at the same time to prevent overreaction and unexpected complications. In this context, the magnitude of surgical stress exerted on the patient is of paramount importance. Several factors, either controllable or not, are known to contribute to the development and amplification of the 'surgical stress response'. Therefore, they should be taken into consideration by both surgical practitioners and other medical specialties involved in the management of the traumatised patient. (C) 2006 Elsevier Ltd. All rights reserved.

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页码：S3 / S9

页数：7

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