Synthesis and biological activities of novel furo[2,3,4-jk][2]benzazepin-4(3H)-one derivatives

被引：11

作者：

Ando, Kumiko

Akai, Yukiko

Kunitomo, Jun-ichi

Yokomizo, Takehiko

Nakajima, Hidemitsu

Takeuchi, Tadayoshi

Yamashita, Masayuki

Ohta, Shunsaku

Ohishi, Takahiro

Ohishi, Yoshitaka

机构：

[1] Mukogawa Womens Univ, Sch Pharmaceut Sci, Nishinomiya, Hyogo 6638179, Japan

[2] Kyushu Univ, Grad Sch Med Sci, Dept Biochem Med, Higashi Ku, Fukuoka 8128582, Japan

[3] Osaka Prefecture Univ, Grad Sch Life & Environm Sci, Dept Vet Pharmacol, Sakai, Osaka 5998531, Japan

[4] Kyoto Pharmaceut Univ, Yamashina Ku, Kyoto 6078414, Japan

[5] Doshisha Univ, Grad Sch Engn, Kyoto 6100394, Japan

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2007年 / 5卷 / 04期

关键词：

D O I：

10.1039/b614510h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel seven-membered lactam formation method has been established by intramolecular ring closure reaction of 4-bromo-(E)-3-[(2-alkylvinyl)carbonylamino]benzo[b]furans (17) under Heck coupling conditions. A number of furo[2,3,4-jk][2]benzazepin-4(3H)-ones (20), tricyclicbenzo[b]furans, have been prepared by this method and evaluated for their leukotriene B-4 (LTB4) receptor and poly(ADP-ribose) polymerase-1 (PARP-1) inhibitory activities.

引用

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页码：655 / 663

页数：9

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