Six months of postmarketing experience with adjunctive lacosamide in patients with pharmacoresistant focal epilepsy at a tertiary epilepsy center in Germany

被引：47

作者：

Wehner, Tim ^{[1
]}

Bauer, Sebastian ^{[1
]}

Hamer, Hajo M. ^{[1
]}

Hattemer, Katja ^{[1
]}

Immisch, Ilka ^{[1
]}

Knake, Susanne ^{[1
]}

Nowak, Mareike ^{[1
]}

Reif, Philipp S. ^{[1
]}

Strzelczyk, Adam ^{[1
]}

Rosenow, Felix ^{[1
]}

机构：

[1] Univ Marburg, Dept Neurol, Interdisciplinary Epilepsy Ctr, D-35039 Marburg, Germany

来源：

EPILEPSY & BEHAVIOR | 2009年 / 16卷 / 03期

关键词：

Pharmacoresistant; Partial onset seizures; Partial epilepsy; Add-on therapy; Lacosamide; Pharmacotherapy; Weight loss; PARTIAL-ONSET SEIZURES; EFFICACY; SAFETY;

D O I：

10.1016/j.yebeh.2009.07.043

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

010107 [宗教学]; 030301 [社会学]; 070906 [古生物学及地层学（含古人类学）];

摘要：

We report our 6 months of experience with adjunctive lacosamide in 25 patients with pharmacoresistant focal epilepsy. Baseline characteristics of our patients were similar to those of the populations in the three clinical trials that evaluated lacosamide for refractory focal epilepsy. One patient experienced sustained seizure freedom for 5 months; two more patients had nonsustained periods of seizure freedom of I and 4 months. A total of eight patients (32%) reported a greater than 50% reduction in seizure frequency. Thirteen patients (52%) reported side effects during the titration, mostly dizziness, fatigue, nausea, and gait instability. In five patients (20%), these disappeared during the maintenance phase and/or with dose reduction. Two patients lost more than 10% of their body weight. Otherwise, in terms of efficacy and adverse effects, our data mirror the profile of lacosamide described in the three clinical trials. Substantial weight loss may occur in individual patients. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：423 / 425

页数：3

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