Very late relapses in glioblastoma long-term survivors

被引：20

作者：

Baehr, Oliver ^{[1
,2
]}

Herrlinger, Ulrich ^{[2
,3
]}

Weller, Michael ^{[2
,4
]}

Steinbach, Joachim P. ^{[1
,2
]}

机构：

[1] Univ Hosp, Dept Neurol & Neurosurg, Dr Senckenberg Inst Neurooncol, D-60528 Frankfurt, Germany

[2] Univ Hosp, Dept Gen Neurol, D-72076 Tubingen, Germany

[3] Univ Hosp, Div Clin Neurooncol, Dept Neurol, D-53105 Bonn, Germany

[4] Univ Zurich Hosp, Dept Neurol, CH-8091 Zurich, Switzerland

来源：

JOURNAL OF NEUROLOGY | 2009年 / 256卷 / 10期

关键词：

MULTIFORME;

D O I：

10.1007/s00415-009-5167-6

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Long-term survival of patients with histologically confirmed glioblastoma is a rare event with figures in the range of 2-3% for 5-year survival (Scott et al. in Ann Neurol 46:183-188, 1999; McLendon and Halperin in Cancer 98:1745-1748, 2003; Krex et al. in Brain 130:2596-2606, 2007). Prognosis and further clinical course of these patients beyond 5 years after diagnosis are in essence unknown with only anecdotal reports of patients surviving for 10 years or more (Salvati et al. J Neurooncol 36:61-64, 1998). We here report on the extended follow-up (mean, 139.4 months) of a cohort of glioblastoma long-term survivors. Very late relapses occurred in many patients even after more than 10 years of progression-free survival.

引用

页码：1756 / 1758

页数：3

共 6 条

[1]

Long-term survival with glioblastoma multiforme [J].