SNAP-23 is located in the basolateral plasma membrane of rat pancreatic acinar cells

被引：63

作者：

Gaisano, HY

Sheu, L

Wong, PPC

Klip, A

Trimble, WS

机构：

[1] HOSP SICK CHILDREN,RES INST,DIV CELL BIOL,TORONTO,ON M5G 1X82,CANADA

[2] UNIV TORONTO,TORONTO HOSP,DEPT MED,TORONTO,ON M5S 1A8,CANADA

[3] UNIV TORONTO,TORONTO HOSP,DEPT BIOCHEM,TORONTO,ON M5S 1A8,CANADA

[4] UNIV TORONTO,TORONTO HOSP,DEPT PHYSIOL,TORONTO,ON M5S 1A8,CANADA

来源：

FEBS LETTERS | 1997年 / 414卷 / 02期

基金：

英国医学研究理事会;

关键词：

exocytosis; pancreatitis; SNARE; rat pancreas;

D O I：

10.1016/S0014-5793(97)01013-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The SNARE hypothesis proposes that specificity of exocytosis is regulated by the appropriate interactions between the vesicle (v-) SNARE and the target membrane (t-) SNAREs. We show here that pancreatic acinar cells express the SNAP-25 t-SNARE homolog SNAP-23, and find that this t-SNARE is most highly concentrated on the basolateral plasma membrane while being expressed below detectable levels iu endocrine islets within the same tissue. This is the first localization of SNAP-23 within a polarized tissue and suggests that this t-SNAREs may interact with syntaxin-4 to mediate basolateral secretion. (C) 1997 Federation of European Biochemical Societies.

引用

页码：298 / 302

页数：5

共 23 条

[1] PHASIC RELEASE OF NEWLY SYNTHESIZED SECRETORY PROTEINS IN THE UNSTIMULATED RAT EXOCRINE PANCREAS [J].