Searching for migraine genes: Exclusion of 290 cM out of the whole human genome

被引：27

作者：

Monari, L

Mochi, M

Valentino, ML

Arnaldi, C

Cortelli, P

DeMonte, A

Pierangeli, G

Prologo, G

Scapoli, C

Soriani, S

Montagna, P

机构：

[1] UNIV BOLOGNA, CTR STUDIO CEFALEE, NEUROL CLIN, I-40123 BOLOGNA, ITALY

[2] UNIV FERRARA, IST PEDIAT, I-44100 FERRARA, ITALY

[3] UNIV FERRARA, DIPARTIMENTO BIOL EVOLUT, I-44100 FERRARA, ITALY

来源：

ITALIAN JOURNAL OF NEUROLOGICAL SCIENCES | 1997年 / 18卷 / 05期

关键词：

migraine; lod score; sib-pair analysis; serotonin; calcium channel;

D O I：

10.1007/BF02083304

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A linkage and association analysis was made on 14 Italian families with recurrent migraine. We analyzed five chromosomal regions surrounding the candidate genes 5HT(1D)(1p36.3-34.3), 5HT(1B)(6q13), 5HT(2A) (13q14-21), 5HT transporter (17q11.2-12), CACNLB1 (17q11.2-22) and FHM(19p13), using 29 DNA polymorphic markers. All two-point lod scores were negative, and the chi 2 sib-pair analyses were not significant, thus indicating the probable exclusion of these regions as sites of migraine genes in our population.

引用

页码：277 / 282

页数：6

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