Broadening the scope of 1,2,4-triazine synthesis by the application of microwave technology

被引：80

作者：

Zhao, ZJ ^{[1
]}

Leister, WH ^{[1
]}

Strauss, KA ^{[1
]}

Wisnoski, DD ^{[1
]}

Lindsley, CW ^{[1
]}

机构：

[1] Merck Res Labs, Technol Enabled Synth Grp, Dept Med Chem, West Point, PA 19486 USA

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 06期

关键词：

D O I：

10.1016/S0040-4039(02)02845-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

By the application of microwave technology, a general protocol has been developed for the rapid synthesis of diverse 3,5,6-trisubstituted 1,2,4-triazines in excellent yield and purity, including many previously unknown 3-heterocyclic-1,2,4-triazines. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：1123 / 1127

页数：5

共 18 条

[1]

[Anonymous], 1995, PROG HETEROCYCL CHEM, DOI [10.1016/S0959-6380(06)80016-4, DOI 10.1016/S0959-6380(06)80016-4]

[2] INDOLE AS A DIENOPHILE IN INVERSE ELECTRON DEMAND DIELS-ALDER REACTIONS .3. INTRAMOLECULAR REACTIONS WITH 1,2,4-TRIAZINES TO ACCESS THE CANTHINE SKELETON [J].

BENSON, SC ;

LI, JH ;

SNYDER, JK .

JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (20) :5285-5287

[3]

BETTATI M, 2002, Patent No. 0238568

[4] DIELS-ALDER REACTIONS OF HETEROCYCLIC AZADIENES - SCOPE AND APPLICATIONS [J].

BOGER, DL .

CHEMICAL REVIEWS, 1986, 86 (05) :781-793

[5]

BONDINELL WE, 2002, Patent No. 0276984

[6]

Gröger H, 2000, CHIM OGGI, V18, P12

[7] Dry media reactions [J].

Kidwai, M .

PURE AND APPLIED CHEMISTRY, 2001, 73 (01) :147-151

[8] STUDIES IN THE TRIAZINE SERIES INCLUDING A NEW SYNTHESIS OF 1-2-4-TRIAZINES [J].

LAAKSO, PV ;

ROBINSON, R ;

VANDREWALA, HP .

TETRAHEDRON, 1957, 1 (1-2) :103-118

[9]

LEISTER WH, UNPUB J COMB CHEM

[10] Microwave assisted organic synthesis -: a review [J].

Lidström, P ;

Tierney, J ;

Wathey, B ;

Westman, J .

TETRAHEDRON, 2001, 57 (45) :9225-9283

← 1 2 →