IgG subclasses specific to Staphylococcus epidermidis and Propionibacterium acnes in patients with acne vulgaris

被引:40
作者
Ashbee, HR
Muir, SR
Cunliffe, WJ
Ingham, E
机构
[1] UNIV LEEDS,DEPT MICROBIOL,SKIN RES CTR,LEEDS LS2 9JT,W YORKSHIRE,ENGLAND
[2] UNIV LEEDS,DEPT DERMATOL,LEEDS LS2 9JT,W YORKSHIRE,ENGLAND
关键词
D O I
10.1111/j.1365-2133.1997.tb03660.x
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
IgG subclasses specific to Staphylococcus epidermidis and Propionibacterium acnes were determined in sera from patients with mild, moderate or severe acne and from a control group. Titres specific to S. epidermidis were all within the same range and did not differ between groups. The titres of IgG subclasses specific to P. acnes did vary between groups. IgG(1) and IgG(3) were significantly higher in severe acne patients compared with moderate acne patients, while IgG(2) was significantly higher in moderate and severe patients compared with controls. Titres of IgG(4) did not differ between groups. The pattern of titres observed suggests that, while the antibody response to S. epidermidis is relatively harmless, antibodies to P. acnes may be involved in the pathogenesis of acne vulgaris.
引用
收藏
页码:730 / 733
页数:4
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