Lesion patterns and mechanism of ischemia in internal carotid artery disease - A diffusion-weighted imaging study

被引:67
作者
Kang, DW
Chu, K
Ko, SB
Kwon, SJ
Yoon, BW
Roh, JK
机构
[1] Seoul Univ, Dept Neurol, Med Res Ctr, Seoul Natl Univ Hosp,Neurosci Res Inst, Seoul 110744, South Korea
[2] Seoul Univ, Clin Res Inst, Med Res Ctr, Seoul Natl Univ Hosp,Neurosci Res Inst, Seoul 110744, South Korea
[3] Natl Inst Neurol Disorders & Stroke, Sect Stroke Diagnost & Therapeut, Bethesda, MD USA
关键词
D O I
10.1001/archneur.59.10.1577
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Context: Although embolism and low-flow phenomenon are the 2 main mechanisms of stroke in internal carotid artery (ICA) occlusive disease, the mechanism of border-zone infarction remains controversial. Diffusion-weighted imaging (DWI) can more easily detect small or multiple ischemic lesions than conventional imaging. Objectives: To investigate the ischemic lesion patterns on DWI and to discuss the mechanisms of stroke in ICA disease. Design: Case series. Setting: A tertiary referral center. Patients: We enrolled 35 consecutive patients who had an acute ischemic stroke and (greater than or equal to70%) stenosis or an occlusion of the extracranial ICA confirmed by cerebral angiography and an acute relevant stroke lesion on DWI within 1 week of onset, but without cardiac sources of embolism and tandem intracranial arterial disease. Main Outcome Measures: The lesion pattern on DWI was categorized as territorial or border zone. Multiple ischemic lesions were defined as noncontiguous lesions on DWI in more than 1 vascular territory. Results: There were 3 distinctive stroke lesion patterns. (1) A territorial lesion without a border-zone lesion was found in 21 patients: superficial and superficial territorial in 9, superficial and deep territorial in 7, and single in 5. (2) A border-zone lesion with or without a territorial lesion was found in 10 patients: border zone and territorial in 9 and border zone alone in 1. (3) Bilateral hemispheric lesions were found in 4 patients. Multiple ischemic lesions were found in 29 (82.9%) of the 35 patients. No patient had episodes of hemodynamic compromise. Conclusions: An acute ischemic lesion in ICA occlusive disease is mainly multiple. Border-zone infarction was mostly associated with territorial infarction. These results support the fact that embolism is the predominant stroke mechanism in ICA occlusive disease.
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页码:1577 / 1582
页数:6
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