Lipopolysaccharide increases resistin gene expression in vivo and in vitro

被引：135

作者：

Lu, SC

Shieh, WY

Chen, CY

Hsu, SC

Chen, HL

机构：

[1] Natl Taiwan Univ, Coll Med, Dept Biochem & Mol Biol, Taipei 100, Taiwan

[2] Natl Taiwan Univ, Coll Agr, Dept Agr Chem, Taipei 10764, Taiwan

[3] Natl Taiwan Univ, Coll Med, Hepatitis Res Ctr, Taipei 10764, Taiwan

来源：

FEBS LETTERS | 2002年 / 530卷 / 1-3期

关键词：

resistin; lipopolysaccharide; inflammation; adipocyte; monocyte;

D O I：

10.1016/S0014-5793(02)03450-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Although resistin has been thought to be an important link between obesity and diabetes, recent results do not support this hypothesis. We speculated that resistin may be involved in inflammatory processes and be induced by inflammatory stimuli. In this study, we tested whether lipopolysaccharide (LPS) induced resistin expression in rats. The results show that resistin mRNA levels in white adipose tissue and white blood cells were increased by LPS treatment. LPS also increased resistin mRNA levels in 3T3-L1 adipocytes and human peripheral blood monocytes. The results suggest that resistin is involved in insulin resistance and probably in other inflammatory responses. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

收藏

页码：158 / 162

页数：5

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