Temperature and pH Double Responsive Hybrid Cross-Linked Micelles Based on P(NIPAAm-co-MPMA)-b-P(DEA): RAFT Synthesis and "Schizophrenic" Micellization

被引：111

作者：

Chang, Cong ^{[1
,2
]}

Wei, Hua ^{[1
,2
]}

Feng, Jun ^{[1
,2
]}

Wang, Zong-Chun ^{[1
,2
,3
]}

Wu, Xiao-Jun ^{[1
,2
]}

Wu, De-Qun ^{[1
,2
]}

Cheng, Si-Xue ^{[1
,2
]}

Zhang, Xian-Zheng ^{[1
,2
]}

Zhuo, Ren-Xi ^{[1
,2
]}

机构：

[1] Wuhan Univ, Key Lab Biomed Polymers, Minist Educ, Wuhan 430072, Peoples R China

[2] Wuhan Univ, Dept Chem, Wuhan 430072, Peoples R China

[3] Wuhan Univ, Renmin Hosp, Dept Pharm, Wuhan 430072, Peoples R China

来源：

MACROMOLECULES | 2009年 / 42卷 / 13期

基金：

中国国家自然科学基金;

关键词：

BLOCK-COPOLYMER; DIBLOCK COPOLYMERS; DRUG-DELIVERY; FABRICATION; KINETICS; PNIPAAM; STAR;

D O I：

10.1021/ma900492v

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Poly(N-isopropylacrylamide-co-3-(trimethoxysilyl)propyl methacrylate)-b-poly(2-(diethylamino)ethyl methacrylate) (P(NIPAAm-co-MPMA)-b-P(DEA)) copolymer was synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization. The temperature and pH responsive schizophrenic micellization behaviors of P(NIPAAm-co-MPMA)-b-P(DEA) and the cross-linking of P-(NIPAAm-co-MPMA) blocks using inorganic silica-based cross-linking strategy were investigated in detail. Transmission electron microscopy (TEM) showed that the resultant core cross-linked (CCL) and shell cross-linked (SCL) micelles displayed regular spherical shapes with different sizes in N,N'-dimethylformamide (DMF) and aqueous media. The structure changes of CCL and SCL micellcs at different pHs and temperatures were characterized by H-1 NMR. Optical absorption measurements showed that the lower critical solution temperatures (LCSTs) of the CCL and SCL micelles were 37.5 and 40.5 degrees C, respectively. In vitro drug release study showed that the drug-loaded CCL and SCL micelles displayed thermoresponsive and pH double responsive release behaviors.

引用

页码：4838 / 4844

页数：7

共 39 条

[1] Polymer micelles with cross-linked ionic cores for delivery of anticancer drugs [J].