Stimulation of guinea pig isolated atria by aflatoxins

被引：7

作者：

Abdel-Haq, H ^{[1
]}

Palmery, M ^{[1
]}

Leone, MG ^{[1
]}

Saso, L ^{[1
]}

Silvestrini, B ^{[1
]}

机构：

[1] Univ Rome La Sapienza, Dept Pharmacol Nat Subst & Gen Physiol, Rome, Italy

来源：

TOXICOLOGY IN VITRO | 2000年 / 14卷 / 03期

关键词：

aflatoxin(s); heart; atria; cardiac toxicity; isoprenaline; stimulation;

D O I：

10.1016/S0887-2333(00)00013-8

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Acute effects of aflatoxins (AF), and in particular cardiac actions, have not been examined as much as chronic toxicity. Thus, in the present study we evaluated the effects of specific AF on isolated guinea pig atria. Isoprenaline (ISO, 4 x 10(-9)), AFB(1) (3 x 10(-6) and 6 x 10(-5) M) and AFG(1) (3 x 10(-6) and 6 x 10(-6) M) contracted the isolated guinea pig atria, leaving the preparation hyperresponsive to ISO. These properties of AF are of interest as they could be responsible of certain cardiotoxic effects described in the literature. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：193 / 197

页数：5

共 33 条

[1] EFFECT OF LOW-LEVEL OF DIETARY AFLATOXINS ON BALADI RABBITS [J].

ABDELHAMID, AM ;

ELSHAWAF, I ;

ELAYOTY, SA ;

ALI, MM ;

GAMIL, T .

ARCHIV FUR TIERERNAHRUNG-ARCHIVES OF ANIMAL NUTRITION, 1990, 40 (5-6) :517-537

[2]

ANGSUBHAKORN S, 1981, J AM VET MED ASSOC, V178, P274

[3]

Borgatti A R, 1979, Boll Soc Ital Biol Sper, V55, P2253

[4]

BORTELL R, 1983, AM J VET RES, V44, P2110

[5]

BUSBY WF, 1984, JCHEM CARCINOGENS AM, V1, P945

[6] ACUTE TOXICITY OF AFLATOXIN B1 IN GUINEA-PIGS [J].

BUTLER, WH .

JOURNAL OF PATHOLOGY AND BACTERIOLOGY, 1966, 91 (01) :277-&

[7] Performance and gastro-intestinal response of broiler chickens fed on cereal grain-based foods soaked in water [J].

Yasar, S ;

Forbes, JM .

BRITISH POULTRY SCIENCE, 1999, 40 (01) :65-76

[8] MECHANISM OF AFLATOXIN CARCINOGENESIS [J].

EATON, DL ;

GALLAGHER, EP .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1994, 34 :135-172

[9]

EDDS GT, 1973, J AM VET MED ASSOC, V162, P304

[10] A COMPARISON OF BETA-ADRENORECEPTOR STIMULANT PROPERTIES OF ISOPRENALINE, WITH THOSE OF ORCIPRENALINE, SALBUTAMOL, SOTERENOL AND TRIMETOQUINOL ON ISOLATED ATRIA AND TRACHEA OF GUINEA-PIG [J].

FARMER, JB ;

KENNEDY, I ;

LEVY, GP ;

MARSHALL, RJ .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1970, 22 (01) :61-&

← 1 2 3 4 →