Clinical efficacy and safety comparison of adapalene gel and tretinoin gel in the treatment of acne vulgaris: Europe and US multicenter trials

被引：68

作者：

Cunliffe, WJ

Caputo, R

Dreno, B

Forstrom, L

Heenen, M

Orfanos, CE

Privat, Y

Aguilar, AR

Meynadier, J

Alirezai, M

Jablonska, S

Shalita, A

Weiss, JS

Chalker, DK

Ellis, CN

Greenspan, A

Katz, HI

Kanto, I

Millikan, LE

Swinehart, JM

Swinyer, L

Whitmore, C

Czernielewski, J

Verschoore, M

机构：

[1] GEN INFIRM,LEEDS LS1 3EX,W YORKSHIRE,ENGLAND

[2] INST SCI DERMATOL,MILAN,ITALY

[3] HOP HOTEL DIEU,DERMATOL SERV,NANTES,FRANCE

[4] UNIV HELSINKI,CENT HOSP,DEPT DERMATOL,HELSINKI,FINLAND

[5] UNIV CENT HOSP,DEPT DERMATOL,HELSINKI,FINLAND

[6] FREE UNIV BRUSSELS,HOP ERASME,SERV DERMATOL,B-1070 BRUSSELS,BELGIUM

[7] UNIV BERLIN,MED CTR BENJAMIN FRANKLIN,BERLIN,GERMANY

[8] CTR CARNOT FORBIN,AIX PROVENCE,FRANCE

[9] UNIV MADRID,HOSP CLIN,CATEDRAT DERTMATOL,MADRID,SPAIN

[10] CHU MONTPELLIER,HOP ST CHARLES,DERMATOL CLIN,MONTPELLIER,FRANCE

[11] KLIN DERMATOL AM,WARSAW,POLAND

[12] SUNY HLTH SCI CTR,BROOKLYN,NY 11203

[13] INT RES SERV,PORT CHESTER,NY

[14] EMORY UNIV,ATLANTA,GA 30322

[15] MED COLL GEORGIA,AUGUSTA,GA 30912

[16] UNIV MICHIGAN,ANN ARBOR,MI 48109

[17] TKL RES,MAYWOOD,IL

[18] MINNESOTA CLIN STUDY CTR,FRIDLEY,MN

[19] RES TESTING LABS INC,GREAT NECK,NY

[20] TULANE UNIV,NEW ORLEANS,LA 70118

[21] TULANE UNIV,DENVER,CO

[22] COLORADO MED RES CTR,DENVER,CO

[23] EDUC & RES FDN,LYNCHBURG,VA

[24] LABS GALDERMA,LEVALLOIS PERRET,FRANCE

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 1997年 / 36卷 / 06期

关键词：

D O I：

10.1016/S0190-9622(97)70056-2

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background: Adapalene is a new chemical entity that exhibits tretinoin-like activities in the terminal differentiation process. Objective: We evaluated a dose range effect of two concentrations of adapalene gel as acne treatment and compared adapalene 0.1% gel with tretinoin 0.025% gel in the treatment of acne patients in two large multicenter studies. Methods: Multicenter. investigator-masked, parallel group studies including 89 acne patients in the dose range study and 591 patients in the concurrent controlled studies were conducted. Results: Adapalene gel 0.1% was significantly more effective in treating acne lesions than 0.03% adapalene gel. Adapalene gel 0.1% was significantly more effective than 0.025% or tretinoin gel in one study and of the same effectiveness in the other study. Adapalene gel was always better tolerated than tretinoin gel. Conclusion: Adapalene 0.1% gel is a safe and effective treatment of acne vulgaris.

引用

页码：S126 / S134

页数：9

共 13 条

[1] CONTROL OF EPIDERMAL DIFFERENTIATION BY A RETINOID ANALOG UNABLE TO BIND TO CYTOSOLIC RETINOIC ACID-BINDING PROTEINS (CRABP) [J].