Natural diversity in the N terminus of the mature vacuolating cytotoxin of Helicobacter pylori determines cytotoxin activity

被引：62

作者：

Letley, DP

Atherton, JC

机构：

[1] Univ Nottingham, Div Gastroenterol, Nottingham NG7 2UH, England

[2] Univ Nottingham, Inst Infect & Immun, Nottingham NG7 2UH, England

来源：

JOURNAL OF BACTERIOLOGY | 2000年 / 182卷 / 11期

关键词：

D O I：

10.1128/JB.182.11.3278-3280.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Naturally occurring noncytotoxic vacA type s2 strains of Helicobacter pylori have a 12-residue extension to the vacuolating cytotoxin (VacA) compared with cytotoxic type s1 strains. We show that adding the region encoding this extension to type s1 vacA completely abolishes vacuolating cytotoxin activity but has no effect on VacA production.

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页码：3278 / 3280

页数：3

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