Inflammation in myocardial injury: mesenchymal stem cells as potential immunomodulators

被引：52

作者：

Yan, Weiang ^{[1
,2
]}

Abu-El-Rub, Ejlal ^{[1
]}

Saravanan, Sekaran ^{[3
]}

Kirshenbaum, Lorrie A. ^{[1
]}

Arora, Rakesh C. ^{[1
,2
]}

Dhingra, Sanjiv ^{[1
]}

机构：

[1] Univ Manitoba, Rady Fac Hlth Sci, Dept Physiol & Pathophysiol, Inst Cardiovasc Sci,St Boniface Hosp,Res Ctr, Winnipeg, MB, Canada

[2] Univ Manitoba, Max Rady Coll Med, Rady Fac Hlth Sci, Sect Cardiac Surg,Dept Surg, Winnipeg, MB, Canada

[3] SASTRA Univ, Ctr Nanotechnol & Adv Biomat, Dept Bioengn, Thanjavur, Tamil Nadu, India

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY | 2019年 / 317卷 / 02期

基金：

加拿大健康研究院;

关键词：

immunomodulation; inflammation; mesenchymal stem cell; myocardial infarction; myocardial repair; NF-KAPPA-B; HEPATOCYTE GROWTH-FACTOR; NECROSIS-FACTOR-ALPHA; MSC-DERIVED EXOSOMES; DEATH GENE BNIP3; TNF-ALPHA; HEART-FAILURE; COMPLEMENT ACTIVATION; OXIDATIVE STRESS; ISCHEMIC-HEART;

D O I：

10.1152/ajpheart.00065.2019

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Ischemic heart disease is a growing worldwide epidemic. Improvements in medical and surgical therapies have reduced early mortality after acute myocardial infarction and increased the number of patients living with chronic heart failure. The irreversible loss of functional cardiomyocytes puts these patients at significant risk of ongoing morbidity and mortality after their index event. Recent evidence suggests that inflammation is a key mediator of postinfarction adverse remodeling in the heart. In this review, we discuss the cardioprotective and deleterious effects of inflammation and its mediators during acute myocardial infarction. We also explore the role of mesenchymal stem cell therapy to limit secondary injury and promote myocardial healing after myocardial infarction.

引用

页码：H213 / H225

页数：13

共 199 条

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