Plasma levels of interleukin-6 and tumor necrosis factor alpha in chronic schizophrenia: Effects of clozapine treatment

被引：116

作者：

Monteleone, P

Fabrazzo, M

Tortorella, A

Maj, M

机构：

[1] Institute of Psychiatry, Faculty of Medicine, University of Naples, 80138 Naples, Largo Madonna delle Grazie

来源：

PSYCHIATRY RESEARCH | 1997年 / 71卷 / 01期

关键词：

atypical neuroleptics; cytokines; immunity; psychosis;

D O I：

10.1016/S0165-1781(97)00036-X

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Plasma levels of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNFalpha) were assessed in 17 chronic schizophrenic patients who had been drug-free for 3 weeks and in 17 age- and sex-matched healthy subjects. Plasma concentrations of both cytokines were measured again in 12 patients after a 10-week treatment with clozapine. Compared with healthy controls, drug-free schizophrenic patients exhibited similar plasma IL-6 concentrations, but significantly higher levels of TNFalpha. After clozapine treatment, blood concentrations of TNFalpha fell to normal levers. These preliminary data support an immune activation in drug-free schizophrenic patients and an effect of clozapine on immune parameters. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：11 / 17

页数：7

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