DNA replication and models for the origin of piRNAs

被引：6

作者：

Bateman, Jack R.

Wu, Chao-ting ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Div Genet, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Div Mol Med, Boston, MA 02115 USA

来源：

BIOESSAYS | 2007年 / 29卷 / 04期

关键词：

D O I：

10.1002/bies.20557

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The piRNA class of small RNAs are distinct from other small RNAs by their similar to 26-31 nucleotide size, single-strandedness and strand-specificity as well as by the clustered arrangement of their origins. Here, we highlight how these features are reminiscent of the mechanisms of DNA replication, and then present three models suggesting that the origin of piRNAs may be mechanistically similar to key processes in DNA replication.

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收藏

页码：382 / 385

页数：4

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