Primary nodal marginal zone B-cell lymphoma: clinical features and prognostic assessment of a rare disease

被引：54

作者：

Arcaini, Luca

Paulli, Marco

Burcheri, Sara

Rossi, Andrea

Spina, Michele

Passamonti, Francesco

Lucioni, Marco

Motta, Teresio

Canzonieri, Vincenzo

Montanari, Mauro

Bonoldi, Emanuela

Gallamini, Andrea

Uziel, Lilj

Crugnola, Monica

Ramponi, Antonio

Montanari, Francesca

Pascutto, Cristiana

Morra, Enrica

Lazzarino, Mario

机构：

[1] Univ Pavia, Div Haematol, Fdn IRCCS, Policlin San Matteo, I-27100 Pavia, Italy

[2] Univ Pavia, Div Pathol, Fdn IRCCS, Policlin San Matteo, I-27100 Pavia, Italy

[3] Osped Riuniti Bergamo, Div Haematol, I-24100 Bergamo, Italy

[4] Osped Riuniti Bergamo, Div Pathol, I-24100 Bergamo, Italy

[5] Natl Canc Inst, Div Med Oncol A, Aviano, Italy

[6] Natl Canc Inst, Dept Pathol, Aviano, Italy

[7] Univ Ancona, Div Haematol, Ancona, Italy

[8] Osped S Bortolo, Dept Pathol, Vicenza, Italy

[9] Osped S Croce, Div Haematol, Cuneo, Italy

[10] Osped San Paolo, Div Oncol, Milan, Italy

[11] Univ Parma, Div Haematol, I-43100 Parma, Italy

[12] AO Maggiore Car, Dept Pathol, Novara, Italy

[13] Osped Niguarda Ca Granda, Div Haematol, Milan, Italy

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2007年 / 136卷 / 02期

关键词：

nodal marginal zone lymphoma; low-grade non-Hodgkin lymphoma; marginal zone; prognosis; hepatitis C virus;

D O I：

10.1111/j.1365-2141.2006.06437.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This study defined the clinical features and assessed the prognosis of 47 patients (17 males, 30 females, median age 63 years) with primary nodal marginal zone B-cell lymphoma. Forty-five per cent had stage IV disease. Hepatitis C virus serology was positive in 24%. According to the Follicular Lymphoma International Prognostic Index (FLIPI), 33% were classified as low-risk, 34% as intermediate-risk, and 33% as high-risk. The 5-year overall survival (OS) was 69%. In univariate analysis worse OS was associated with: FLIPI (P = 0.02), age > 60 years (P = 0.05) and raised lactate dehydrogenase (P = 0.05). In multivariate analysis, only FLIPI predicted a worse OS (P = 0.02).

引用

页码：301 / 304

页数：4

共 12 条

[1] Splenic marginal zone lymphoma: a prognostic model for clinical use [J].