Molecular basis for pre-TCR-mediated utonomous signaling

被引：50

作者：

Yamasaki, Sho ^{[1
]}

Saito, Takashi ^{[1
]}

机构：

[1] RIKEN, Res Ctr Allergy & Immunol, Lab Cell Signaling, Tsurumi Ku, Yokohama, Kanagawa 2300045, Japan

来源：

TRENDS IN IMMUNOLOGY | 2007年 / 28卷 / 01期

关键词：

D O I：

10.1016/j.it.2006.11.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The pre-T-cell receptor (pre=TCR) is a multimeric complex composed of a nascent TCR beta chain, an invariant pre-TCR alpha (pT alpha) chain and CD3 molecules, and is crucial for early T-cell development. Despite its structural similarity to the mature alpha beta TCR, which requires MHC-antigen for receptor triggering, the pre-TCR is proposed to initiate signals in a ligand-independent manner. However, the molecular mechanism underlying the autonomous signaling is still unclear. Recent studies have revealed that pT alpha possesses unique characteristics that promote autonomous signaling. In this review, we summarize current data relating to the molecular mechanism underlying the initiation of pre-TCR-mediated autonomous signaling.

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收藏

页码：39 / 43

页数：5

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