Engineering exosomes as refined biological nanoplatforms for drug delivery

被引：916

作者：

Luan, Xin ^{[1
]}

Sansanaphongpricha, Kanokwan ^{[1
]}

Myers, Ila ^{[1
]}

Chen, Hongwei ^{[1
]}

Yuan, Hebao ^{[1
]}

Sun, Duxin ^{[1
]}

机构：

[1] Univ Michigan, Coll Pharm, Ann Arbor, MI 48105 USA

来源：

ACTA PHARMACOLOGICA SINICA | 2017年 / 38卷 / 06期

关键词：

exosome; nanoparticles; drug delivery systems; imaging probes; therapeutics; CELL-DERIVED EXOSOMES; EXTRACELLULAR VESICLES; DENDRITIC CELLS; CANCER-THERAPY; T-CELLS; NANOPARTICLES; COMMUNICATION; NANOMEDICINE; ACTIVATION; PACLITAXEL;

D O I：

10.1038/aps.2017.12

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Exosomes, a subgroup of extracellular vesicles (EVs), have been recognized as important mediators of long distance intercellular communication and are involved in a diverse range of biological processes. Because of their ideal native structure and characteristics, exosomes are promising nanocarriers for clinical use. Exosomes are engineered at the cellular level under natural conditions, but successful exosome modification requires further exploration. The focus of this paper is to summarize passive and active loading approaches, as well as specific exosome modifications and examples of the delivery of therapeutic and imaging molecules. Examples of exosomes derived from a variety of biological origins are also provided. The biocompatible characteristics of exosomes, with suitable modifications, can increase the stability and efficacy of imaging probes and therapeutics while enhancing cellular uptake. Challenges in clinical translation of exosome-based platforms from different cell sources and the advantages of each are also reviewed and discussed.

引用

页码：754 / 763

页数：10

共 75 条

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