Regulation of Metastases by signal transducer and activator of transcription 3 signaling pathway: Clinical implications

被引：196

作者：

Huang, Suyun

机构：

[1] Univ Texas, MD Anderson Canc Ctr, Dept Neurosurg, Houston, TX 77030 USA

[2] Univ Texas, MD Anderson Canc Ctr, Dept Canc Biol, Houston, TX 77030 USA

[3] Univ Texas, Grad Sch Biomed Sci, Program Canc Biol, Houston, TX USA

来源：

CLINICAL CANCER RESEARCH | 2007年 / 13卷 / 05期

关键词：

POTENT ANTITUMOR-ACTIVITY; EPIDERMAL-GROWTH-FACTOR; DNA-BINDING ACTIVITY; STAT3; ACTIVATION; CANCER-CELLS; CONSTITUTIVE ACTIVATION; ENDOTHELIAL-CELLS; VEGF EXPRESSION; BREAST-TUMORS; TRANSFORMATION;

D O I：

10.1158/1078-0432.CCR-06-2313

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Numerous cytokines, growth factors, and oncogenic proteins activate signal transducer and activator of transcription 3 (Stat3), which has been recognized as one of the common pathways in cancer cells. Stat3 signaling affects the expression and function of a variety of genes that are critical to cell survival, cell proliferation, invasion, angiogenesis, and immune evasion. Evidently, the Stat3 signaling pathway regulates cancer metastasis and constitutes a potential preventive and therapeutic target for cancer metastasis.

引用

页码：1362 / 1366

页数：5

共 49 条

[1]

BARTOLI M, 2005, CANC METASTASIS REV, V24, P315

[2]

Blaskovich MA, 2003, CANCER RES, V63, P1270

[3]

Stat proteins and oncogenesis [J].