Substituted 5,7-diphenyl-pyrrolo[2,3d]pyrimidines:: Potent inhibitors of the tyrosine kinase c-Src

被引：41

作者：

Missbach, M ^{[1
]}

Altmann, E

Widler, L

Susa, M

Buchdunger, E

Mett, H

Meyer, T

Green, J

机构：

[1] Novartis Pharma AG, Therapeut Areas Arthrit & Bone Metab, CH-4002 Basel, Switzerland

[2] Novartis Pharma AG, Dept Oncol, CH-4002 Basel, Switzerland

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 09期

关键词：

D O I：

10.1016/S0960-894X(00)00131-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

5,7-Diphenyl-pyrrolol[2,3d]pyrimidines represent a new class of highly potent inhibitors of the tyrosine kinase c-Src (IC50 < 50 nM) with specificity against a panel of different tyrosine kinases. The substitution pattern on the two phenyl rings determines potency and specificity and provides a means to modulate cellular activity. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：945 / 949

页数：5

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