The caudal periaqueductal gray participates in the activation of brown adipose tissue in rats

被引：35

作者：

Chen, XM

Nishi, M

Taniguchi, A

Nagashima, K

Shibata, M

Kanosue, K

机构：

[1] Osaka Univ, Dept Physiol, Sch Allied Hlth Sci, Fac Med, Osaka 5650871, Japan

[2] Yamanashi Inst Environm Sci, Dept Biometeorol, Yamanashi 4030005, Japan

来源：

NEUROSCIENCE LETTERS | 2002年 / 331卷 / 01期

关键词：

non-shivering thermogenesis; thermoregulation; periaqueductal gray;

D O I：

10.1016/S0304-3940(02)00757-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To investigate the involvement of the periaqueductal gray (PAG) in the control of non-shivering thermogenesis, we tested the effects of electrical or chemical stimulation of the PAG on thermogenesis of brown adipose tissue (BAT) in urethane anesthetized rats. Electrical stimulation (0.1 mA, 33 Hz, 0.5 ms) or application of D,L-homocysteic acid (0.5 mM, 0.3 mul) into the lateral region of the caudal PAG (cPAG) elicited BAT thermogenesis, measured as a rise in the local temperature of interscapular BAT. These results suggest that neurons in the cPAG send excitatory efferent signals for BAT thermogenesis. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

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页码：17 / 20

页数：4

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