Asymmetric resolution of diastereomeric 4-ethoxycarbonyl-5-pentyl-gamma-butyrolactones by crude PLE-mediated hydrolysis

被引：6

作者：

Drioli, S ^{[1
]}

Felluga, F ^{[1
]}

Forzato, C ^{[1
]}

Nitti, P ^{[1
]}

Pitacco, G ^{[1
]}

Valentin, E ^{[1
]}

机构：

[1] UNIV TRIESTE,DIPARTIMENTO SCI CHIM,I-34127 TRIESTE,ITALY

来源：

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC | 1997年 / 3卷 / 1-4期

关键词：

lipase; esterase; asymmetric hydrolysis; gamma-lactones;

D O I：

10.1016/S1381-1177(96)00046-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chemical reduction of diethyl 1-oxo-hexylsuccinate resulted in the formation of the corresponding cis and trans disubstituted gamma-butyrolactones. Both racemic diastereomers were resolved by means of lipolytic enzymes leading to the precursors of interesting natural products such as (-)-methylenolactocin and (-)-phaseolinic acid.

引用

页码：203 / 207

页数：5

共 18 条

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