What clinicians need to know about antioestrogen resistance in breast cancer therapy

被引：38

作者：

Milano, Amalia ^{[1
]}

Dal Lago, Lissandra ^{[1
]}

Sotiriou, Christos ^{[1
]}

Piccart, Martine ^{[1
]}

Cardoso, Fatima ^{[1
]}

机构：

[1] Inst Jules Bordet, Med Oncol & Translat Res Unit, B-1000 Brussels, Belgium

来源：

EUROPEAN JOURNAL OF CANCER | 2006年 / 42卷 / 16期

关键词：

breast cancer; tamoxifen-resistance; predictive marker; AIB1; HER-2; oestrogen receptor; progesterone receptor; cox-2; cyclin E; UPA/PAI-1;

D O I：

10.1016/j.ejca.2006.06.022

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tamoxifen is the drug most used for early breast cancer treatment in oestrogen receptor (ER) positive patients. Unfortunately, despite high ER tumour levels in a tumour, resistance to endocrine therapy, either de novo or acquired after prolonged treatment, can occur. In this review, we will try to summarise the postulated mechanisms of hormonal-resistance, namely, the role of co-regulators and the crosstalk between the HER-2, IGF-IR, Cox-2 and ER pathways. Other predictive markers of tamoxifen-resistance/response, such as cyclin E and UPA/PAI-1, are also discussed. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：2692 / 2705

页数：14

共 128 条

[1]

Abe O, 2005, LANCET, V366, P2087, DOI 10.1016/s0140-6736(05)66544-0

[2]

Andreasen PA, 1997, INT J CANCER, V72, P1, DOI 10.1002/(SICI)1097-0215(19970703)72:1<1::AID-IJC1>3.0.CO

[3]

2-Z

[4] AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer [J].

Anzick, SL ;

Kononen, J ;

Walker, RL ;

Azorsa, DO ;

Tanner, MM ;

Guan, XY ;

Sauter, G ;

Kallioniemi, OP ;

Trent, JM ;

Meltzer, PS .

SCIENCE, 1997, 277 (5328) :965-968

[5] Phenotypic alterations in breast cancer cells overexpressing the nuclear receptor co-activator AIBI [J].

Anzick, SL ;

Azorsa, DO ;

Simons, SS ;

Meltzer, PS .

BMC CANCER, 2003, 3 (1)

[6] Estrogen receptor-positive, progesterone receptor-negative breast cancer: Association with growth factor receptor expression and tamoxifen resistance [J].

Arpino, G ;

Weiss, H ;

Lee, AV ;

Schiff, R ;

De Placido, S ;

Osborne, CK ;

Elledge, RM .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2005, 97 (17) :1254-1261

[7]

ARPINO G, 2004, BREAST CANC RES TREA

[8]

ARTEAGA CL, 1989, CANCER RES, V49, P6237

[9]

ARTEAGA CL, 2004, BREAST CANC RES TREA

[10]

BASERGA R, 1995, CANCER RES, V55, P249

← 1 2 3 4 5 6 7 8 9 10 →