Replacing the nucleohases in DNA with designer molecules

被引：342

作者：

Kool, ET ^{[1
]}

机构：

[1] Stanford Univ, Dept Chem, Stanford, CA 94305 USA

来源：

ACCOUNTS OF CHEMICAL RESEARCH | 2002年 / 35卷 / 11期

关键词：

D O I：

10.1021/ar000183u

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

DNA is not only a carrier of genetic information, but it is also a versatile supramolecular scaffold, arranging smaller organic structures into predesigned geometries. Herein are discussed molecular strategies in which the natural DNA bases on the sugar-phosphate backbone are replaced by other molecules. Some of the base replacements under study include fluorophores, ligands for metals, helix stabilizers, and DNA base shape mimics.

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页码：936 / 943

页数：8

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