Anti-allergic agents from natural sources (4):: Anti-allergic activity of new phloroglucinol derivatives from Mallotus philippensis (Euphorbiaceae)

被引：46

作者：

Daikonya, A

Katsuki, S

Wu, JB

Kitanaka, S

机构：

[1] Nihon Univ, Coll Pharm, Funabashi, Chiba 2748555, Japan

[2] Natl Inst Hlth Sci, Tanegashima Expt Stn Med Plants, Kagoshima 8913604, Japan

[3] China Med Univ, Inst Pharmaceut Chem, Taichung 404, Taiwan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2002年 / 50卷 / 12期

关键词：

Mallotus philippensis; Euphorbiaceae; macrophage; nitric oxide;

D O I：

10.1248/cpb.50.1566

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new phloroglucinol derivatives, mallotophilippen A (1) and B (2) were isolated from the fruits of Mallotus philippensis. These compounds were identified, using chemical and spectral data, as 1-[5,7-dihydroxy-2,2-dimethyl-6-(2,4,6-trihydroxy-3-isobutyryl-5-methyl-benzyl)-2H-chromen-8-yl] -2-methyl-butan-1-one and 1-[6-(3-Acetyl-2,4,6-trihydroxy-5-methyl-benzyl)-5,7-dihydroxy-2,2-dimethyl-2H-chromen-8-yl] -2-methyl-butan-1-one, respectively. They inhibited nitric oxide (NO) production and inducible NO synthase (iNOS) gene expression by a murine macrophage-like cell line (RAW 264.7), which was activated by lipopolysaccharide (LPS) and recombinant mouse interferon-gamma (IFN-gamma). Furthermore, they inhibited histamine release from rat peritoneal mast cells induced by Compound 48/80. These results suggest that the novel phloroglucinol derivatives have anti-inflammatory effects.

引用

页码：1566 / 1569

页数：4

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