Syntheses of emeraldin and purpurin-18 analogs as target-specific photosensitizers for photodynamic therapy

被引：23

作者：

Kozyrev, AN

Zheng, G

Lazarou, E

Dougherty, TJ

Smith, KM

Pandey, RK

机构：

[1] ROSWELL PK CANC INST,DIV RADIAT MED,DEPT RADIAT BIOL,DIV CHEM,BUFFALO,NY 14263

[2] UNIV CALIF DAVIS,DEPT CHEM,DAVIS,CA 95616

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 19期

关键词：

D O I：

10.1016/S0040-4039(97)00621-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Efficient syntheses and mechanisms of the formation of some some novel porphyrins and chlorins with cyclic anhydride, imide and isoimide rings bearing various N-substituents as possible target-specific photosensitizers for photodynamic therapy are presented. Porphyrins with such cyclic ring systems are named as ''emeraldins'' due to their intense green color. This class of compounds show a unique reverse etio- type absorption spectra. (C) 1997 Published by Elsevier Science Ltd.

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页码：3335 / 3338

页数：4

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