The mechanical properties of compacts of microcrystalline cellulose and silicified microcrystalline cellulose

被引：68

作者：

Edge, S

Steele, DF

Chen, AS

Tobyn, MJ

Staniforth, JN ^{[1
]}

机构：

[1] Univ Bath, Dept Pharm & Pharmacol, Pharmaceut Technol Res Grp, Bath BA2 7AY, Avon, England

[2] Univ Bath, Dept Mat Sci & Engn, Bath BA2 7AY, Avon, England

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2000年 / 200卷 / 01期

关键词：

silicified microcrystalline cellulose; mechanical property; strength;

D O I：

10.1016/S0378-5173(00)00343-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The mechanical properties of compacts of unlubricated microcrystalline cellulose and silicified microcrystalline cellulose were evaluated using the diametric tensile test. The results suggested that, under comparable testing conditions, compacts of silicified microcrystalline cellulose exhibited greater strength than those of microcrystalline cellulose. In addition to enhanced strength, silicified microcrystalline cellulose compacts exhibited greater stiffness and required considerably more energy for tensile failure to occur. Comparison of the data with that obtained for a dry blend of silicon dioxide/microcrystalline cellulose suggested that the functionality benefits of silicification were not due to a simple composite material model. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：67 / 72

页数：6

共 14 条

[1]

Bolhuis GK., 1996, PHARM POWDER COMPACT, P419

[2] Water sorption and near IR spectroscopy to study the differences between microcrystalline cellulose and silicified microcrystalline cellulose before and after wet granulation [J].