Effect of a mixture of seven pharmaceuticals on Hyalella azteca over multiple generations

被引：34

作者：

Borgmann, U. ^{[1
]}

Bennie, D. T. ^{[1
]}

Ball, A. L. ^{[1
]}

Palabrica, V. ^{[1
]}

机构：

[1] Environm Canada, Water Sci & Technol Directorate, Burlington, ON L7R 4A6, Canada

来源：

CHEMOSPHERE | 2007年 / 66卷 / 07期

关键词：

Hyalella; pharmaceuticals; chronic toxicity; reproduction;

D O I：

10.1016/j.chemosphere.2006.07.025

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

A mixture of seven common pharmaceutical agents (acetaminophen, diclofenac, gemfibrozil, ibuprofen, naproxen, salicylic acid, and triclosan) was tested for its effects on the freshwater amphipod Hyalella azteca over three generations. The target concentration of each chemical (100 ng 1(-1)) was representative of the upper range observed for these substances in Canadian fresh waters, except in the immediate vicinity of effluent discharges. No statistically significant effects were observed on survival, mating, body size or reproduction. The sex ratio changed slightly to 17% more males. The seven pharmaceuticals tested do not appear to be substances of major concern for Hyalella in most Canadian fresh waters, but significant impacts might be observed in areas closer to effluent discharges. Crown Copyright (c) 2006 Published by Elsevier Ltd. All rights reserved.

引用

页码：1278 / 1283

页数：6

共 33 条

[1] Accumulation of tributyltin in Hyalella azteca as an indicator of chronic toxicity:: Survival, growth, and reproduction [J].

Bartlett, AJ ;

Borgmann, U ;

Dixon, DG ;

Batchelor, SP ;

Maguire, RJ .

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 2004, 23 (12) :2878-2888

[2] Transformation of acetaminophen by chlorination produces the toxicants 1,4-benzoquinone and N-acetyl-p-benzoquinone imine [J].

Bedner, M ;

Maccrehan, WA .

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2006, 40 (02) :516-522

[3] Toxicity and bioaccumulation of thallium in Hyalella azteca, with comparison to other metals and prediction of environmental impact [J].

Borgmann, U ;

Cheam, V ;

Norwood, WP ;

Lechner, J .

ENVIRONMENTAL POLLUTION, 1998, 99 (01) :105-114

[4] Quantification of bioavailable nickel in sediments and toxic thresholds to Hyalella azteca [J].

Borgmann, U ;

Néron, R ;

Norwood, WP .

ENVIRONMENTAL POLLUTION, 2001, 111 (02) :189-198

[5] Sediment toxicity testing with the freshwater amphipod Hyalella azteca:: Relevance and application [J].

Borgmann, U ;

Grapentine, L ;

Norwood, WP ;

Bird, G ;

Dixon, DG ;

Lindeman, D .

CHEMOSPHERE, 2005, 61 (11) :1740-1743

[6] Re-evaluation of metal bioaccumulation and chronic toxicity in Hyalella azteca using saturation curves and the biotic ligand model [J].

Borgmann, U ;

Norwood, WP ;

Dixon, DG .

ENVIRONMENTAL POLLUTION, 2004, 131 (03) :469-484

[7] ACCUMULATION, REGULATION AND TOXICITY OF COPPER, ZINC, LEAD AND MERCURY IN HYALELLA-AZTECA [J].

BORGMANN, U ;

NORWOOD, WP ;

CLARKE, C .

HYDROBIOLOGIA, 1993, 259 (02) :79-89

[8] Pharmaceuticals and personal care products (PPCPs) in surface and treated waters of Louisiana, USA and Ontario, Canada [J].

Boyd, GR ;

Reemtsma, H ;

Grimm, DA ;

Mitra, S .

SCIENCE OF THE TOTAL ENVIRONMENT, 2003, 311 (1-3) :135-149

[9] Waterborne and sediment toxicity of fluoxetine to select organisms [J].

Brooks, BW ;

Turner, PK ;

Stanley, JK ;

Weston, JJ ;

Glidewell, EA ;

Foran, CM ;

Slattery, M ;

La Point, TW ;

Huggett, DB .

CHEMOSPHERE, 2003, 52 (01) :135-142

[10] Occurrence of the pharmaceutical drug clofibric acid and the herbicide mecoprop in various Swiss lakes and in the North Sea [J].

Buser, HR ;

Muller, MD ;

Theobald, N .

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 1998, 32 (01) :188-192

← 1 2 3 4 →