Response to comments on "A common genetic variant is associated with adult and childhood obesity"

被引：5

作者：

Herbert, Alan

Gerry, Norman P.

McQueen, Matthew B.

Heid, Iris M.

Pfeufer, Arne

Illig, Thomas

Wichmann, H. -Erich

Meitinger, Thomas

Hunter, David

Hu, Frank B.

Colditz, Graham

Hinney, Anke

Hebebrand, Johannes

Koberwitz, Kerstin

Zhu, Xiaofeng

Cooper, Richard

Ardlie, Kristin

Lyon, Helen

Hirschhorn, Joel N.

Laird, Nan M.

Lenburg, Marc E.

Lange, Christoph

Christman, Michael F.

机构：

[1] Boston Univ, Dept Genet & Genom, Boston, MA 02118 USA

[2] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[3] GSF Forschungszentrum Umwelt & Gesundheit, Natl Res Ctr, Inst Epidemiol, D-85764 Neuherberg, Germany

[4] GSF, Natl Res Ctr, KORA Grp, D-85764 Neuherberg, Germany

[5] GSF, Natl Res Ctr, Inst Human Genet, D-85764 Neuherberg, Germany

[6] Tech Univ Munich, Inst Human Genet, D-81671 Munich, Germany

[7] Univ Munich, Inst Med Informat Biometry & Epidemiol, Munich, Germany

[8] Harvard Univ, Brigham & Womens Hosp, Nurses Hlth Study, Channing Lab,Sch Med,Dept Med, Boston, MA 02115 USA

[9] Univ Duisburg Essen, Dept Child & Adolescant Psychiat, D-45147 Essen, Germany

[10] Loyola Univ, Med Ctr, Dept Prevent Med & Epidemiol, Maywood, IL 60153 USA

[11] Seracare Life Sci Inc, Genom Collaborat, Cambridge, MA 02139 USA

[12] Childrens Hosp, Program Genom, Boston, MA 02115 USA

[13] Childrens Hosp, Div Genet, Boston, MA 02115 USA

[14] Childrens Hosp, Div Endocrinol, Boston, MA 02115 USA

[15] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

[16] Harvard Univ, Broad Inst, Cambridge, MA 02139 USA

[17] MIT, Cambridge, MA 02139 USA

[18] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA

[19] Harvard Univ, Brigham & Womens Hosp, Sch Med, Channing Lab, Boston, MA 02115 USA

来源：

SCIENCE | 2007年 / 315卷 / 5809期

关键词：

D O I：

10.1126/science.1129763

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Identification of genetic variants affecting complex traits such as obesity is confounded by many types of bias, especially when effect sizes are small. Given our findings of a positive association between rs7566605 and body mass index in four out of five separate samples, a false positive finding cannot be ruled out with certainty but seems unlikely. Meta-analyses of multiple large studies will help refine the estimate of the effects of rs7566605 on body mass index.

引用

页数：2

共 5 条

[1] A common genetic variant is associated with adult and childhood obesity [J].