Dynamic regulation of histone lysine methylation by demethylases

被引：543

作者：

Shi, Yang ^{[1
]}

Whetstine, Johnathan R. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

来源：

MOLECULAR CELL | 2007年 / 25卷 / 01期

关键词：

D O I：

10.1016/j.molcel.2006.12.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent studies demonstrated that histone methylation is not static but is dynamically regulated by histone methyltransferases and the newly discovered histone demethylases. This review discusses the chemical mechanisms for the known and potentially new classes of demethylases, the roles of these demethylases in chromatin and transcription, and their potential biological functions and connections to human diseases.

引用

页码：1 / 14

页数：14

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