Copper(I) catalyzed conjugate addition of Grignard reagents to acrylic acids: Homologation of artemisinic acid and subsequent conversion to 9-substituted artemisinin analogs

被引：19

作者：

Vroman, JA

Khan, IA

Avery, MA

机构：

[1] UNIV MISSISSIPPI,DEPT CHEM,UNIVERSITY,MS 38677

[2] UNIV MISSISSIPPI,SCH PHARM,DEPT MED CHEM,UNIVERSITY,MS 38677

[3] UNIV MISSISSIPPI,NATL CTR DEV NAT PROD,UNIVERSITY,MS 38677

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 35期

关键词：

D O I：

10.1016/S0040-4039(97)01428-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new route to novel 9-substituted-10-deoxoartemisinin analogs (13, 14) was developed employing photoxygenation of homologated derivatives of artemisinic acid (9, 10). Conjugate addition to the acrylate moiety of artemisinic acid 2 was made possible by in situ protection as a silyl ester, Cu(I)-catalyzed 1,4-addition of RMgX, and deprotection. (C) 1997 Elsevier Science Ltd.

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页码：6173 / 6176

页数：4

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