Exercise training effects on skeletal muscle plasticity and IGF-1 receptors in frail elders

被引:39
作者
Urso, Maria L.
Singh, Maria A. Fiatarone
Ding, Wenjing
Evans, William J.
Cosmas, Arthur C.
Manfredi, Thomas G. [1 ]
机构
[1] Univ Rhode Isl, Energy Metab Lab, Kingston, RI 02881 USA
[2] Univ Massachusetts, Dept Exercise Sci, Amherst, MA 01003 USA
[3] Tufts Univ, Jean Mayer US Dept Agr, Human Nutr Res Ctr Aging, Nutr Exercise Physiol & Sarcopenia Lab, Boston, MA 02111 USA
[4] Univ Sydney, Sch Exercise & Sport Sci, Lidcombe, NSW 1825, Australia
[5] Univ Arkansas Med Sci, Vet Affairs Med Ctr, Donald W Reyolds Dept Geriat & Geriat Res Educ, Little Rock, AR 72114 USA
[6] Univ Arkansas Med Sci, Vet Affairs Med Ctr, Ctr Clin, Little Rock, AR 72114 USA
[7] Univ Rhode Isl, Kingston, RI 02881 USA
[8] Univ Connecticut, Storrs, CT 06269 USA
关键词
aging; exercise; IGF-1; receptors; skeletal muscle;
D O I
10.1007/s11357-005-1629-7
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 [法学]; 0303 [社会学]; 100203 [老年医学];
摘要
Age-related sarcopenia inhibits mobility, increasing the risk for developing many diseases, including diabetes, arthritis, osteoporosis, and heart disease. Tissue plasticity, or the ability to regenerate following stress, has been a subject of question in aging humans. We assessed the impact of 10-weeks of resistance training on markers of skeletal muscle plasticity and insulin growth factor-1 (IGF-1) receptor density in a sub sample of subjects who, in an earlier study, demonstrated enhanced immunohistochemical labeling of IGF following resistance training. Muscle biopsies from the vastus lateralis of five elderly men and women were taken prior to and following 10 weeks of resistance training (N = 3) or a control period ( N = 2). Immunogold labeling and quantitative electron microscopy techniques were used to analyze markers of IGF-1 receptor density and tissue plasticity. The experimental subjects showed a 161 +/- 93.7% increase in Z band damage following resistance training. Myofibrillar central nuclei increased 296 +/- 120% ( P = 0.029) in the experimental subjects. Changes in the percent of damaged Z bands were associated with alterations in the presence of central nuclei (r = 0.668; P = 0.0347). Post hoc analysis revealed that the relative pre/post percent changes in myofibrillar Z band damage and central nuclei were not statistically different between the control and exercise groups. Exercise training increased myofibrillar IGF-1 receptor densities in the exercise subjects ( P = 0.008), with a non-significant increase in the control group. Labeling patterns suggested enhanced receptor density around the Z bands, sarcolemma, and mitochondrial and nuclear membranes. Findings from this study suggest that the age-related downregulation of the skeletal muscle IGF-1 system may be reversed to some extent with progressive resistance training. Furthermore, skeletal muscle tissue plasticity in the frail elderly is maintained at least to some extent as exemplified by the enhancement of IGF-1 receptor density and markers of tissue regeneration.
引用
收藏
页码:117 / 125
页数:9
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