Connexin 43 signalling and cardioprotection

被引：52

作者：

Boengler, K. ^{[1
]}

Schulz, R. ^{[1
]}

Heusch, G. ^{[1
]}

机构：

[1] Univ Klinikum Essen, Inst Pathophysiol, Zentrum Innere Med, D-45122 Essen, Germany

来源：

HEART | 2006年 / 92卷 / 12期

关键词：

D O I：

10.1136/hrt.2005.066878

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Connexin (Cx) 43 is the predominant protein forming gap junctions and non-junctional hemichannels in ventricular myocardium. The Cx43 proteins are central to the cardioprotection afforded by ischaemic preconditioning (IP). The specific role of mitochondrial Cx43 in protection by IP is reviewed.

引用

页码：1724 / 1727

页数：4

共 50 条

[1] Molecular cloning and functional analysis of a novel Cx43 partner protein CIP150
Akiyama, M
Ishida, N
Ogawa, T
Yogo, K
Takeya, T
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 335 (04) : 1264 - 1271
[2] Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from α-particle irradiated to nonirradiated cells
Azzam, EI
de Toledo, SM
Little, JB
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (02) : 473 - 478
[3] Oxygen radicals released during ischemic preconditioning contribute to cardioprotection in the rabbit myocardium
Baines, CP
Goto, M
Downey, JM
[J]. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 1997, 29 (01) : 207 - 216
[4] Regulation of purified and reconstituted connexin 43 hemichannels by protein kinase C-mediated phosphorylation of serine 368
Bao, XY
Reuss, L
Altenberg, GA
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (19) : 20058 - 20066
[5] Mechanism of regulation of the gap junction protein connexin 43 by protein kinase C-mediated phosphorylation
Bao, XY
Altenberg, GA
Reuss, L
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2004, 286 (03): : C647 - C654
[6] Dephosphorylation and intracellular redistribution of ventricular connexin43 during electrical uncoupling induced by ischemia
Beardslee, MA
Lerner, DL
Tadros, PN
Laing, JG
Beyer, EC
Yamada, KA
Kléber, AG
Schuessler, RB
Saffitz, JE
[J]. CIRCULATION RESEARCH, 2000, 87 (08) : 656 - 662
[7] Connexin 43 in cardiomyocyte mitochondria and its increase by ischemic preconditioning
Boengler, K
Dodoni, G
Rodriguez-Sinovas, A
Cabestrero, A
Ruiz-Meana, M
Gres, P
Konietzka, I
Lopez-Iglesias, C
Garcia-Dorado, D
Di Lisa, F
Heusch, G
Schulz, R
[J]. CARDIOVASCULAR RESEARCH, 2005, 67 (02) : 234 - 244
[8] BOENGLER K, 2005, CIRCULATION, V112, P157
[9] Delayed uncoupling contributes to the protective effect of heptanol against ischaemia in the rat isolated heart
Chen, BP
Mao, HJ
Fan, FY
Bruce, IC
Xia, Q
[J]. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2005, 32 (08): : 655 - 662
[10] The carboxy-tail of connexin-43 localizes to the nucleus and inhibits cell growth
Dang, XT
Doble, BW
Kardami, E
[J]. MOLECULAR AND CELLULAR BIOCHEMISTRY, 2003, 242 (1-2) : 35 - 38

← 1 2 3 4 5 →