Characterization of a nuclear-factor-kappa B (NFκB) genetic marker in type 1 diabetes (T1DM) families

被引：20

作者：

Gylvin, T ^{[1
]}

Bergholdt, R ^{[1
]}

Nerup, J ^{[1
]}

Pociot, F ^{[1
]}

机构：

[1] Steno Diabet Ctr, DK-2820 Gentofte, Denmark

来源：

GENES AND IMMUNITY | 2002年 / 3卷 / 07期

关键词：

signal transduction; transcription factor; cytokines; susceptibility gene; TDT-test; autoimmunity;

D O I：

10.1038/sj.gene.6363916

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Cytokine-induced beta-cell death is an important factor in the pathogenesis of type 1 diabetes mellitus (T1DM). The transcription factor NFkappaB plays an important role in cytokine-induced gene activation. Hence, NFKB1 is a possible candidate gene for T1DM disposition. A polymorphic (CA) dinucleotide repeat microsatellite has been identified near the NFKB1 gene. In a recent case-control study certain alleles of this NFKB1 microsatellite marker showed strong association to T1DM. The aim of our study was to investigate whether the association between the NFKB1 marker and T1DM could be confirmed in a Danish family collection. No T1DM association for any allele of the NFKB1 microsatellite marker could however be demonstrated in Danish T1DM families. In conclusion, we could not confirm the highly significant T1DM association of certain alleles of the NFKB1 marker previously reported.

引用

收藏

页码：430 / 432

页数：3

相关论文

共 15 条

[1] Control of apoptosis by Rel/NF-κB transcription factors [J].

Barkett, M ;

Gilmore, TD .

ONCOGENE, 1999, 18 (49) :6910-6924

[2] A comprehensive analysis of cytokine-induced and nuclear factor-κB-dependent genes in primary rat pancreatic β-cells [J].

Cardozo, AK ;

Heimberg, H ;

Heremans, Y ;

Leeman, R ;

Kutlu, B ;

Kruhoffer, M ;

Orntoft, T ;

Eizirik, DL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (52) :48879-48886

[3] Seven regions of the genome show evidence of linkage to type 1 diabetes in a consensus analysis of 767 multiplex families [J].

Cox, NJ ;

Wapelhorst, B ;

Morrison, VA ;

Johnson, L ;

Pinchuk, L ;

Spielman, RS ;

Todd, JA ;

Concannon, P .

AMERICAN JOURNAL OF HUMAN GENETICS, 2001, 69 (04) :820-830

[4] A choice of death - the signal-transduction of immune-mediated beta-cell apoptosis [J].

Eizirik, DL ;

Mandrup-Poulsen, T .

DIABETOLOGIA, 2001, 44 (12) :2115-2133

[5] Genetic linkage and association studies of Type I diabetes: challenges and rewards [J].

Field, LL .

DIABETOLOGIA, 2002, 45 (01) :21-35

[6] NFκB Polymorphisms and susceptibility to type 1 diabetes [J].

Hegazy, DM ;

O'Reilly, DA ;

Yang, BM ;

Hodgkinson, AD ;

Millward, BA ;

Demaine, AG .

GENES AND IMMUNITY, 2001, 2 (06) :304-308

[7] Inhibition of cytokine-induced NF-κB activation by adenovirus-mediated expression of a NF-κB super-repressor prevents β-cell apoptosis [J].

Heimberg, H ;

Heremans, Y ;

Jobin, C ;

Leemans, R ;

Cardozo, AK ;

Darville, M ;

Eizirik, DL .

DIABETES, 2001, 50 (10) :2219-2224

[8] Proteome analysis of interleukin-1β-induced changes in protein expression in rat islets of Langerhans [J].

Larsen, PM ;

Fey, SJ ;

Larsen, MR ;

Nawrocki, A ;

Andersen, HU ;

Kähler, H ;

Heilmann, C ;

Voss, MC ;

Roepstorff, P ;

Pociot, F ;

Karlsen, AE ;

Nerup, J .

DIABETES, 2001, 50 (05) :1056-1063

[9] The role of interleukin-1 in the pathogenesis of IDDM [J].

MandrupPoulsen, T .

DIABETOLOGIA, 1996, 39 (09) :1005-1029

[10] Isolation and radiation hybrid mapping of a highly polymorphic CA repeat sequence at the human nuclear factor kappa-beta subunit 1 (NFKB1) locus [J].

Ota, N ;

Nakajima, T ;

Shirai, Y ;

Emi, M .

JOURNAL OF HUMAN GENETICS, 1999, 44 (02) :129-130