Protective properties of 6-gingerol-rich fraction from Zingiber officinale (Ginger) on chlorpyrifos-induced oxidative damage and inflammation in the brain, ovary and uterus of rats

被引：114

作者：

Abolaji, Amos O. ^{[1
]}

Ojo, Mercy ^{[1
]}

Afolabi, Tosin T. ^{[1
]}

Arowoogun, Mary D. ^{[1
]}

Nwawolor, Darlinton ^{[1
]}

Farombi, Ebenezer O. ^{[1
]}

机构：

[1] Univ Ibadan, Fac Basic Med Sci, Coll Med, Dept Biochem,Drug Metab & Mol Toxicol Res Labs, Ibadan, Nigeria

来源：

CHEMICO-BIOLOGICAL INTERACTIONS | 2017年 / 270卷

关键词：

Chlorpyrifos; Zingiber officinale; Female reprotoxicity; Neurotoxicity; Oxidative damage; Inflammation; GLUTATHIONE S-TRANSFERASES; INDUCED TOXICITY; NITRIC-OXIDE; DROSOPHILA-MELANOGASTER; REPRODUCTIVE TOXICITY; SUPEROXIDE-DISMUTASE; ANTIOXIDANT ENZYMES; LIPID-PEROXIDATION; ULCERATIVE-COLITIS; EXPRESSION;

D O I：

10.1016/j.cbi.2017.03.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Chlorpyrifos (CPF) is an organophosphorus pesticide widely used in agricultural applications and household environments. 6-Gingerol-rich fraction from Zingiber officinale (Ginger, 6-GRF) has been reported to possess potent anti-oxidative, anti-inflammatory and anti-apoptotic properties. Here, we investigated the protective properties of 6-GRF on CPF-induced oxidative damage and inflammation in the brain, ovary and uterus of rats. Five groups of rats containing 14 rats/group received corn oil (control), CPF (5 mg/kg), 6-GRF (100 mg/Kg), CPF (5 mg/kg) + 6-GRF (50 mg/kg) and CPF (5 mg/kg) + 6-GRF (100 mg/kg) through gavage once per day for 35 days respectively. The results showed that 6-GRF protected against CPF-induced increases in oxidative stress ((hydrogen peroxide (H2O2) and malondialdehyde (MDA)), inflammatory (myeloperoxidase (MPO), nitric oxide (NO) and tumour necrosis factor-alpha (TNF- alpha)), and apoptotic (caspase-3) markers. Also, 6-GRF improved the activities of antioxidant enzymes catalase, superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione S-transferase (GST) as well as glutathione (GSH) level in the brain, ovary and uterus of rats exposed to CPF (p < 0.05). Overall, the protective effects of 6-GRF on CPF-induced toxicity in the brain and reproductive organs of rats may be due to its potent antioxidative, anti-inflammatory and antiapoptotic properties. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：15 / 23

页数：9

共 59 条

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