The metastatic cascade in prostate cancer

被引：108

作者：

Arya, Manit ^{[1
]}

Bott, Simon R. ^{[1
]}

Shergill, Iqbal S. ^{[1
]}

Ahmed, Flashim U. ^{[1
]}

Williamson, Magali ^{[1
]}

Patel, Fliten R. ^{[1
]}

机构：

[1] UCL, Inst Urol, Prostate Canc Res Ctr, London W1W 7EJ, England

来源：

SURGICAL ONCOLOGY-OXFORD | 2006年 / 15卷 / 03期

基金：

英国医学研究理事会;

关键词：

prostate cancer; metastasis; molecular genetics; prognosis;

D O I：

10.1016/j.suronc.2006.10.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Morbidity and mortatity due to prostate cancer are mainly a result of prostate cancer metastases. After the initial neoplastic transformation of cells, the process of metastasis involves a series of sequential steps, which involve neoangiogenesis and lymphangiogenesis, loss of adhesion with migration away from the primary tumour and entry into the systemic vasculature or lymphatics. Metastatic growth in sites such as lymph nodes and bone marrow then involves the specific non-random homing of prostate cancer cells. An appreciation and understanding of this metastatic cascade in relation to prostate cancer is clinically important in order to stratify men with prostate cancer into prognostic groups. Moreover, it is crucial in the future development of therapies that can prevent metastases. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：117 / 128

页数：12

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