Accelerating regional atrophy rates in the progression from normal aging to Alzheimer's disease

被引：79

作者：

Sluimer, Jasper D. ^{[1
,2
,3
]}

van der Flier, Wiesje M. ^{[2
,4
]}

Karas, Giorgos B. ^{[1
,2
,3
]}

van Schijndel, Ronald ^{[3
,6
]}

Barnes, Josephine ^{[7
]}

Boyes, Richard G. ^{[7
]}

Cover, Keith S. ^{[5
]}

Olabarriaga, Silvia D. ^{[8
]}

Fox, Nick C. ^{[4
,7
]}

Scheltens, Philip ^{[2
,4
]}

Vrenken, Hugo ^{[2
,3
,5
]}

Barkhof, Frederik ^{[1
,2
,3
]}

机构：

[1] Vrije Univ Amsterdam, Med Ctr, Dept Diagnost Radiol, NL-1007 MB Amsterdam, Netherlands

[2] Vrije Univ Amsterdam, Med Ctr, Alzheimer Ctr, NL-1007 MB Amsterdam, Netherlands

[3] Vrije Univ Amsterdam, Med Ctr, Image Anal Ctr, NL-1007 MB Amsterdam, Netherlands

[4] Vrije Univ Amsterdam, Med Ctr, Dept Neurol, NL-1007 MB Amsterdam, Netherlands

[5] Vrije Univ Amsterdam, Med Ctr, Dept Phys & Med Technol, NL-1007 MB Amsterdam, Netherlands

[6] Vrije Univ Amsterdam, Med Ctr, Dept Informat, NL-1007 MB Amsterdam, Netherlands

[7] UCL, Inst Neurol, Dementia Res Ctr, London, England

[8] Univ Amsterdam, Acad Med Ctr, Dept Clin Epidemiol Biostat & Bioinformat, NL-1105 AZ Amsterdam, Netherlands

来源：

EUROPEAN RADIOLOGY | 2009年 / 19卷 / 12期

基金：

英国医学研究理事会;

关键词：

Alzheimer's disease; Magnetic resonance imaging; Atrophy; Image processing; Computer-assisted; MILD COGNITIVE IMPAIRMENT; GRAY-MATTER LOSS; HIPPOCAMPAL ATROPHY; BRAIN ATROPHY; FLUID REGISTRATION; DEMENTIA; MRI; CONVERSION; DIAGNOSIS; MEMORY;

D O I：

10.1007/s00330-009-1512-5

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

We investigated progression of atrophy in vivo, in Alzheimer's disease (AD), and mild cognitive impairment (MCI). We included 64 patients with AD, 44 with MCI and 34 controls with serial MRI examinations (interval 1.8 +/- 0.7 years). A nonlinear registration algorithm (fluid) was used to calculate atrophy rates in six regions: frontal, medial temporal, temporal (extramedial), parietal, occipital lobes and insular cortex. In MCI, the highest atrophy rate was observed in the medial temporal lobe, comparable with AD. AD patients showed even higher atrophy rates in the extramedial temporal lobe. Additionally, atrophy rates in frontal, parietal and occipital lobes were increased. Cox proportional hazard models showed that all regional atrophy rates predicted conversion to AD. Hazard ratios varied between 2.6 (95% confidence interval (CI) = 1.1-6.2) for occipital atrophy and 15.8 (95% CI = 3.5-71.8) for medial temporal lobe atrophy. In conclusion, atrophy spreads through the brain with development of AD. MCI is marked by temporal lobe atrophy. In AD, atrophy rate in the extramedial temporal lobe was even higher. Moreover, atrophy rates also accelerated in parietal, frontal, insular and occipital lobes. Finally, in nondemented elderly, medial temporal lobe atrophy was most predictive of progression to AD, demonstrating the involvement of this region in the development of AD.

引用

页码：2826 / 2833

页数：8

共 40 条

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