DNA structure dependent checkpoints as regulators of DNA repair

被引:120
作者
Carr, AM [1 ]
机构
[1] Univ Sussex, Genome Damage & Stabil Ctr, Falmer BN1 9RQ, Sussex, England
关键词
SMC; BRCT-domain; cell cycle; recombination;
D O I
10.1016/S1568-7864(02)00165-9
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Checkpoint proteins were initially identified because their loss of function resulted in defects in cell cycle arrest in response to genotoxic treatments. Initially, the analysis of checkpoint pathways concentrated on their function as signal transducers and how the checkpoint signals were communicated to the core cell cycle machinery and transcriptional apparatus. Although some of the early genetic analysis indicated a complex relationship between DNA replication, DNA repair and the checkpoint pathways, it is only now becoming apparent that checkpoint proteins regulate multiple DNA repair and replication functions. Furthermore, recent data suggest that some checkpoint proteins may participate directly in DNA repair events. In this review I summarise the current models for DNA structure-dependent checkpoint activation and review the evidence linking checkpoint proteins both directly and indirectly to DNA repair. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:983 / 994
页数:12
相关论文
共 77 条
[1]   Mrc1 transduces signals of DNA replication stress to activate Rad53 [J].
Alcasabas, AA ;
Osborn, AJ ;
Bachant, J ;
Hu, FH ;
Werler, PJH ;
Bousset, K ;
Furuya, K ;
Diffley, JFX ;
Carr, AM ;
Elledge, SJ .
NATURE CELL BIOLOGY, 2001, 3 (11) :958-965
[2]   DNA-REPAIR MUTANTS DEFINING G2 CHECKPOINT PATHWAYS IN SCHIZOSACCHAROMYCES-POMBE [J].
ALKHODAIRY, F ;
CARR, AM .
EMBO JOURNAL, 1992, 11 (04) :1343-1350
[3]   IDENTIFICATION AND CHARACTERIZATION OF NEW ELEMENTS INVOLVED IN CHECKPOINT AND FEEDBACK CONTROLS IN FISSION YEAST [J].
ALKHODAIRY, F ;
FOTOU, E ;
SHELDRICK, KS ;
GRIFFITHS, DJF ;
LEHMANN, AR ;
CARR, AM .
MOLECULAR BIOLOGY OF THE CELL, 1994, 5 (02) :147-160
[4]   Differential timing and control of noncrossover and crossover recombination during meiosis [J].
Allers, T ;
Lichten, M .
CELL, 2001, 106 (01) :47-57
[5]   Cnd2 has dual roles in mitotic condensation and interphase [J].
Aono, N ;
Sutani, T ;
Tomonaga, T ;
Mochida, S ;
Yanagida, M .
NATURE, 2002, 417 (6885) :197-202
[6]   CLONING AND CHARACTERIZATION OF RAD21 AN ESSENTIAL GENE OF SCHIZOSACCHAROMYCES-POMBE INVOLVED IN DNA DOUBLE-STRAND-BREAK REPAIR [J].
BIRKENBIHL, RP ;
SUBRAMANI, S .
NUCLEIC ACIDS RESEARCH, 1992, 20 (24) :6605-6611
[7]   Damage tolerance protein Mus81 associates with the FHA1 domain of checkpoint kinase Cds1 [J].
Boddy, MN ;
Lopez-Girona, A ;
Shanahan, P ;
Interthal, H ;
Heyer, WD ;
Russell, P .
MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (23) :8758-8766
[8]   Mus81-Eme1 are essential components of a Holliday junction resolvase [J].
Boddy, MN ;
Gaillard, PHL ;
McDonald, WH ;
Shanahan, P ;
Yates, JR ;
Russell, P .
CELL, 2001, 107 (04) :537-548
[9]   The ATM homologue MEC1 is required for phosphorylation of replication protein A in yeast [J].
Brush, GS ;
Morrow, DM ;
Hieter, P ;
Kelly, TJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (26) :15075-15080
[10]   Phosphorylation of the replication protein A large subunit in the Saccharomyces cerevisiae checkpoint response [J].
Brush, GS ;
Kelly, TJ .
NUCLEIC ACIDS RESEARCH, 2000, 28 (19) :3725-3732