Pathways and consequences:: Hedgehog signaling in human disease

被引:104
作者
Mullor, JL
Sánchez, P
Altaba, ARI
机构
[1] NYU, Sch Med, Skirball Inst, Dev Genet Program, New York, NY 10016 USA
[2] NYU, Sch Med, Skirball Inst, Dept Cell Biol, New York, NY 10016 USA
关键词
D O I
10.1016/S0962-8924(02)02405-4
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Signaling pathways that play a fundamental role during development are turning out to underlie many disease states when misregulated. Here, we review some of the recent findings in the Hedgehog (Hh) pathway and the role it plays in different human diseases. We present a summary of the diseases that result from the inactivation or inappropriate activation of the Hh pathway. The human phenotypes generally fit the findings in model organisms and help to identify some potential targets for therapy.
引用
收藏
页码:562 / 569
页数:8
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