The role of immunomodulatory oligonucleotides in prevention of OVA-induced Eustachian tube dysfunction

被引：5

作者：

Ebert, Charles S., Jr.

Rose, Austin S.

Patel, Mihir R.

Hardy, Stuart M.

Kandimalla, Ekambar R.

Agrawal, Sudhir

Prazma, Jiri

Pillsbury, Harold C., III

机构：

[1] Univ N Carolina, Neurosci Hosp G0412, Dept Otolaryngol Head & Neck Surg, Chapel Hill, NC 27599 USA

[2] Idera Pharmaceut Inc, Cambridge, MA USA

来源：

INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY | 2006年 / 70卷 / 12期

关键词：

oligonucteotide; allergy; otitis media; transtympanic; Eustachian tube dysfunction;

D O I：

10.1016/j.ijporl.2006.07.016

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Objective: To evaluate the potential role of immunomodulatory otigonucleotides (IMO) in the prevention of OVA-induced Eustachian tube dysfunction (ETD) in a rat model. Methods: Brown-Norway rats were sensitized to ovalbumin (OVA) and randomized to receive pre-treatment with IMO or phosphate buffered saline (PBS). After systemic sensitization, subjects received a transtympanic OVA challenge followed by evaluation of the Eustachian tube's dynamic function. Results: Pre-treatment of OVA sensitized animals with IMO normalized passive opening and closing Eustachian tube pressures, improved active clearance of negative pressure in the middle ear, and resulted in reduced mean mucociliary transit times compared to untreated OVA-sensitized animals (P < 0.001). Conclusion: These data demonstrate that pre-treatment with IMO prevent OVA-induced ETD in the rat. IMO treatment in the future may offer considerable promise in the management of OME in children. (C) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

页码：2019 / 2026

页数：8

共 40 条

[1] Novel immunomodulatory oligonucleotides prevent development of allergic airway inflammation and airway hyperresponsiveness in asthma [J].

Agrawal, DK ;

Edwan, J ;

Kandimalla, ER ;

Yu, D ;

Bhagat, L ;

Wang, DQ ;

Agrawal, S .

INTERNATIONAL IMMUNOPHARMACOLOGY, 2004, 4 (01) :127-138

[2]

ALHO OP, 1995, ARCH OTOLARYNGOL, V121, P839

[3] Microbiology and immunology [J].

Barenkamp, SJ ;

Ogra, PL ;

Bakaletz, LO ;

Chonmaitree, T ;

Heikkinen, T ;

Hurst, DS ;

Kawauchi, H ;

Kurono, Y ;

Leiberman, A ;

Murphy, TF ;

Patel, JA ;

Sih, TM ;

St Geme, JW ;

Stenfors, LE .

ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY, 2005, 114 (01) :60-85

[4] Role of allergy in eustachian tube blockage and otitis media with effusion: A review [J].

Bernstein, JM .

OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 1996, 114 (04) :562-568

[5] ANATOMY AND PHYSIOLOGY OF EUSTACHIAN-TUBE AND MIDDLE-EAR RELATED TO OTITIS-MEDIA [J].

BLUESTONE, CD ;

DOYLE, WJ .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1988, 81 (05) :997-1003

[6] Epidemiology and pathogenesis of chronic suppurative otitis media: implications for prevention and treatment [J].

Bluestone, CD .

INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY, 1998, 42 (03) :207-223

[7] Direct expenditures related to otitis media diagnoses: Extrapolations from a pediatric medicaid cohort [J].

Bondy, J ;

Berman, S ;

Glazner, J ;

Lezotte, D .

PEDIATRICS, 2000, 105 (06) :art. no.-e72

[8]

Casselbrant, 2003, EVIDENCE BASED OTITI, P147

[9]

Daly K A, 1999, Pediatr Rev, V20, P85, DOI 10.1542/pir.20-3-85

[10] Epidemiology, natural history, and risk factors [J].

Daly, KA ;

Hoffman, HJ ;

Casselbrant, ML ;

Kvaerner, KJ ;

Rovers, MM ;

Uhari, M ;

Zielhuis, G .

ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY, 2005, 114 (01) :8-15

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