CpG oligonucleotides improve the protective immune response induced by the licensed anthrax vaccine

被引：31

作者：

Klinman, Dennis M.

Xie, Hang

Ivins, Bruce E.

机构：

[1] US FDA, Sect Retroviral Immunol, CBER, Bethesda, MD 20892 USA

[2] USA, Med Res Inst Infect Dis, Bacteriol Div, Frederick, MD 21702 USA

来源：

OLIGONUCLEOTIDE THERAPEUTICS | 2006年 / 1082卷

关键词：

anthrax; vaccine; adjuvant; CpG oligonucleotide; protection;

D O I：

10.1196/annals.1348.030

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs act as immune adjuvants, improving the response elicited by a coadministered vaccine. Combining CpG ODN with anthrax vaccine adsorbed (AVA, the licensed human vaccine) increases the speed, magnitude, and avidity of the resultant antibody response. IgG Abs against anthrax protective antigen (PA) protect mice, guinuea pigs, and rhesus macaques from infection.

引用

页码：137 / 150

页数：14

共 52 条

[1] Order-restricted tests for stratified comparisons of binomial proportions [J].