Expression of alpha 4-1 and alpha 5 nicotinic cholinoceptor mRNA in the aging rat cerebral cortex

被引:11
作者
Birtsch, C
Wevers, A
Traber, J
Maelicke, A
Bloch, W
Schroder, H
机构
[1] UNIV COLOGNE, INST ANAT 2, D-50931 COLOGNE, GERMANY
[2] BAYER AG, D-5600 WUPPERTAL, GERMANY
[3] UNIV MAINZ, INST PHYSIOL CHEM & PATHOBIOCHEM, D-6500 MAINZ, GERMANY
[4] UNIV COLOGNE, INST ANAT 1, D-5000 COLOGNE, GERMANY
关键词
aging; rat brain; cerebral cortex; nicotinic acetylcholine receptor; subunits; alpha; 4-1; 5; in situ hybridization; nonisotopic; riboprobe; digoxigenin;
D O I
10.1016/S0197-4580(97)80316-8
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Although important in neurodegeneration, systematic studies of nicotinic acetylcholine receptor expression in normal aging human brains are difficult to perform. We have studied the expression of nicotinic receptor alpha 4-1 and alpha 5 mRNA in the frontal and parietal isocortex of 3- (young adult), 24- (late middle aged), and 33-month-old (old) rats by nonisotopic in situ hybridization. In all groups transcripts were mainly present in layer nmr and V pyramidal neurons. The numerical densities of alpha 4-1 mRNA-containing neurons with respect to those of cresyl violet-stained neurons decreased with aging in the rat frontal and parietal cortex, while those of alpha 5 mRNA-containing neurons were not affected. These findings point to an age-related decrease of the percentages of numerical densities of alpha 4-1 mRNa-containing neurons, which has to be taken into account as a possible substrate for the well-known decrease of nicotine binding sites in the aging cerebral cortex. (C) 1997 Elsevier Science Inc.
引用
收藏
页码:335 / 342
页数:8
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