Role of serotonin for scoliotic deformity in pinealectomized chicken

被引:58
作者
Machida, M
Miyashita, Y
Murai, I
Dubousset, J
Yamada, T
Kimura, J
机构
[1] NIHON UNIV, SCH MED, DEPT BIOCHEM, ITABASHI KU, TOKYO, JAPAN
[2] HOSP ST VINCENT DE PAUL, DEPT ORTHOPAED SURG, PARIS, FRANCE
[3] UNIV IOWA, COLL MED, DEPT NEUROL, IOWA CITY, IA 52242 USA
[4] KYOTO UNIV, FAC MED, DEPT NEUROL, KYOTO 606, JAPAN
关键词
experimental scoliosis; idiopathic scoliosis; pathogenesis; serotonin;
D O I
10.1097/00007632-199706150-00004
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Study Design. The effect of intraperitoneal injection of 5-hydroxytryptophan (5-HTP) versus control in pinealectomized chickens. Objective. To find if the serotonin may have some role in the cause or treatment of idiopathic scoliosis. Summary of Background Data. One of the causes of idiopathic scoliosis is thought to be the disruption of postural reflex. Serotonin has been proposed to have a crucial role in maintaining normal postural muscle tone or postural equilibrium. Method. Forty pinealectomized chickens served as controls, and an additional 40 pinealectomized chickens received daily intraperitoneal injections of 5-hydroxytryptophan, a precursor of serotonin, which can pass through the blood-brain barrier. Spine radiographs were examined to measure the scoliotic deformity. Results. Scoliosis developed in all 40 pinealectomized chickens (control), whereas only 28 chickens in the 5-hydroxytryptophan-treated group (6 in severe, 22 in mild) had scoliosis developed. The remaining 12 chickens grew up with normal spines. Mast chickens with mild scoliosis did not have curve progression but continued to have wedged vertebrae. Conclusion. Serotonin deficit secondary to a defect of melatonin may have disturbed postural muscle tone or postural equilibrium resulting in scoliosis in pinealectomized chicken. Prevention from the development of scoliosis or its progression in chickens treated with 5-hydroxytryptophan suggests that serotonin may have potential therapeutic value.
引用
收藏
页码:1297 / 1301
页数:5
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